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asunaprevir

Small moleculeexperimental

Asunaprevir is an experimental drug candidate for the treatment of hepatitis C. It was undergoing development by Bristol-Myers Squibb and has completed Phase III clinical trials in 2013. — Wikipedia

Clinical trial activity

44 trials · 37 clinical orgs · 0 marketing orgs

Phase 1
12
Phase 2
29
Phase 3
13
Phase 4
3

Earliest trial started Dec 1, 1999 (NCT01062737)

Timeline

1990s

  1. Jan 1, 1999

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2ncc(OC)c3ccc(Cl)cc23)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)C(=O)NS(=O)(=O)C1CC1
Mol. weight
748.3 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • asunaprevir
  • asunaprevir
  • asunaprevir
  • asunaprevir
  • asunaprevir
  • asunaprevir
  • asunaprevir
  • asunaprevir
  • bms-650032
  • bms-650032
  • bms-650032
  • bms-650032
  • bms-650032
  • sunvepra
  • sunvepra
  • sunvepra

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT03794258Phase 2Mar 1, 2019Humanity & Health Research Centre
NCT03004625Phase 3Nov 1, 2016Chang Gung University, China Medical University, Kaohsiung Medical University, National Cheng Kung University, National Taiwan University, Taipei Veteran General hospital
NCT02580474Phase 4Feb 1, 2016Bristol-Myers Squibb, Catholic University of Korea, Cheongju St. Mary's Hospital, Chungnam National University, Dankook University, Eulji University, Konkuk University, Konyang University, Korea University, Soonchunhyang University, Yonsei University
NCT02639585Phase 4Dec 1, 2015Pusan National University
NCT02496078Phase 3Aug 1, 2015Bristol-Myers Squibb
NCT02292966Phase 4Jul 1, 2015Bristol-Myers Squibb, University of New South Wales
NCT02470858Phase 2Jan 1, 2015Emory University, Humanity & Health Research Centre, People's Liberation Army of China
NCT02323594Phase 1Dec 1, 2014Bristol-Myers Squibb, PPD
NCT02309450Phase 2Dec 1, 2014Bristol-Myers Squibb, French National Agency for Research on AIDS and Viral Hepatitis, Hospital Avicenne
NCT02175966Phase 2Jul 1, 2014Bristol-Myers Squibb
NCT02098616N/AJul 1, 2014Bristol-Myers Squibb, Department of Veteran Affairs, National Cancer Institute (NCI), Southern California Institute for Research and Education
NCT02175602Phase 1Jun 1, 2014Bristol-Myers Squibb, PPD
NCT02170727Phase 3Jun 1, 2014Bristol-Myers Squibb
NCT02103569Phase 1Apr 1, 2014Bristol-Myers Squibb
NCT02108639Phase 1Apr 1, 2014Bristol-Myers Squibb
NCT02123654Phase 3Apr 1, 2014Bristol-Myers Squibb
NCT02095860Phase 1Apr 1, 2014Bristol-Myers Squibb
NCT02124044Phase 2Feb 1, 2014Bristol-Myers Squibb, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
NCT02045693Phase 1Feb 1, 2014Bristol-Myers Squibb
NCT02045966Phase 1Feb 1, 2014Bristol-Myers Squibb
Showing 20 of 44 trials
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Organizations

Research & Development (37)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Bristol-Myers SquibbFor profit383052008
French National Agency for Research on AIDS and Viral HepatitisGovernment3312012
Humanity & Health Research CentreAcademic/Hospital2212015
PPDFor profit2012014
Bobigny University HospitalAcademic/Hospital1012013
Catholic University of KoreaAcademic/Hospital1112016
Chang Gung UniversityAcademic/Hospital1012016
Cheongju St. Mary's HospitalAcademic/Hospital1012016
China Medical UniversityAcademic/Hospital1012016
Chungnam National UniversityAcademic/Hospital1012016
Dankook UniversityAcademic/Hospital1012016
Department of Veteran AffairsGovernment1012014
Emory UniversityAcademic/Hospital1012015
Erasmus University RotterdamAcademic/Hospital1012014
Eulji UniversityAcademic/Hospital1012016
Foundation for Liver ResearchAcademic/Hospital1112014
Hospital AvicenneAcademic/Hospital1012014
Kaohsiung Medical UniversityAcademic/Hospital1112016
Konkuk UniversityAcademic/Hospital1012016
Konyang UniversityAcademic/Hospital1012016
37 organizations
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