mgd013
mAbexperimentalMulti-specific
Clinical trial activity
6 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
2
Phase 3
1
Phase 4
0
Earliest trial started Aug 18, 2017 (NCT03219268)
Timeline
Indications
Studied for
- Biliary Tract Neoplasms · Phase 1
- Breast Neoplasms · Phase 1
- Carcinoma, Hepatocellular · Phase 1/Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 1
- Cholangiocarcinoma · Phase 1
- Endometrial Neoplasms · Phase 1
- Esophageal Neoplasms · Phase 2/Phase 3
- Head and Neck Neoplasms · Phase 2
- Hematologic Neoplasms · Phase 1
- Melanoma · Phase 1
- Neoplasms · Phase 1
- Ovarian Neoplasms · Phase 1
- Small Cell Lung Carcinoma · Phase 1
- Squamous Cell Carcinoma of Head and Neck · Phase 2
- Stomach Neoplasms · Phase 2/Phase 3
- Triple Negative Breast Neoplasms · Phase 1
- Uterine Cervical Neoplasms · Phase 1
Mechanism of action
- Lymphocyte activation gene 3 proteinINHIBITOR
Lymphocyte activation gene 3 protein inhibitor
- Programmed cell death protein 1INHIBITOR
Programmed cell death protein 1 inhibitor
- Programmed cell death 1 ligand 1Immunity, passive
CD274 immunity, passive
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- Yes
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4594578 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04634825 | Phase 2 | Mar 17, 2021 | MacroGenics |
| NCT04653038 | Phase 1 | Oct 29, 2020 | Chinese Academy of Medical Sciences, Zai Lab Pty. Ltd. |
| NCT04212221 | Phase 1/Phase 2 (Phase 2) | Feb 29, 2020 | People's Liberation Army of China, Zai Lab Pty. Ltd. |
| NCT04178460 | Phase 1 | Dec 31, 2019 | Zai Lab Pty. Ltd. |
| NCT04082364 | Phase 2/Phase 3 (Phase 3) | Sep 30, 2019 | MacroGenics, Zai Lab Pty. Ltd. |
| NCT03219268 | Phase 1 | Aug 18, 2017 | MacroGenics |
Showing 6 of 6 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Zai Lab Pty. Ltd. | For profit | 4 | 3 | 3 | 2019 |
| MacroGenics | For profit | 3 | 3 | 3 | 2017 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 0 | 1 | 2020 |
| People's Liberation Army of China | Government | 1 | 0 | 1 | 2020 |
4 organizations
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