emavusertib
Small moleculeexperimental
Clinical trial activity
10 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Dec 28, 2017 (NCT03328078)
Timeline
Indications
Studied for
- Adenocarcinoma · Phase 1
- Anemia · Phase 2
- Biliary Tract Neoplasms · Phase 1
- Carcinoma, Transitional Cell · Phase 1
- Colorectal Neoplasms · Phase 1
- Esophageal Neoplasms · Phase 1
- Leukemia, Myeloid, Acute · Phase 1
- Lymphoma · Phase 1
- Melanoma · Phase 1/Phase 2
- Myelodysplastic Syndromes · Phase 2
- Neoplasms · Phase 1
- Pancreatic Neoplasms · Phase 1
- Stomach Neoplasms · Phase 1
Mechanism of action
IRAK4 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Cc1cc(-c2nc(C(=O)Nc3cc4oc(N5CCOCC5)nc4nc3N3CC[C@@H](O)C3)co2)ccn1- Mol. weight
- 491.51 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4783351 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07271667 | Phase 2 | Dec 31, 2025 | Curis |
| NCT07107750 | Phase 1 | Oct 31, 2025 | Curis, Washington University in St. Louis |
| NCT06696768 | Phase 1 | Dec 30, 2024 | National Cancer Institute (NCI), Yale University |
| NCT06439836 | Phase 1 | Dec 16, 2024 | Mount Sinai Hospital, Canada, National Cancer Institute (NCI) |
| NCT05669352 | Phase 1/Phase 2 (Phase 2) | Aug 31, 2023 | Merck, University of Florida |
| NCT05685602 | Phase 1 | Jun 12, 2023 | National Cancer Institute (NCI), Yale University |
| NCT05187182 | Phase 1 | Nov 30, 2022 | Curis, Washington University in St. Louis |
| NCT05178342 | Phase 2 | Jan 1, 2022 | Curis, University of Leipzig |
| NCT04278768 | Phase 1 | Feb 19, 2020 | Curis |
| NCT03328078 | Phase 1 | Dec 28, 2017 | Curis |
Showing 10 of 10 trials
Page 1 / 1
Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Curis | For profit | 6 | 3 | 2 | 2017 |
| National Cancer Institute (NCI) | Government | 3 | 3 | 1 | 2023 |
| Washington University in St. Louis | Academic/Hospital | 2 | 2 | 1 | 2022 |
| Yale University | Academic/Hospital | 2 | 0 | 1 | 2023 |
| Merck | For profit | 1 | 0 | 1 | 2023 |
| Mount Sinai Hospital, Canada | Academic/Hospital | 1 | 0 | 1 | 2024 |
| University of Florida | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Leipzig | Academic/Hospital | 1 | 1 | 1 | 2022 |
8 organizations
Page 1 / 1