ibogaine
Small moleculeexperimental
Ibogaine is a psychoactive indole alkaloid derived from plants such as Tabernanthe iboga, characterized by hallucinogenic and oneirogenic effects. Traditionally used by Central African foragers, it has undergone controversial research for the treatment of substance use disorders. Ibogaine exhibits complex pharmacology by interacting with multiple neurotransmitter systems, notably affecting opioid, serotonin, sigma, and NMDA receptors, while its metabolite noribogaine primarily acts as a serotonin reuptake inhibitor and κ-opioid receptor agonist. — Wikipedia
Clinical trial activity
3 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Aug 31, 2018 (NCT03380728)
Timeline
Indications
Mechanism of action
- Serotonin transporterINHIBITOR
SLC6A4 inhibitor
- Dopamine transporterINHIBITOR
SLC6A3 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13- Mol. weight
- 310.44 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaIbogaine ↗
- ChEMBLCHEMBL222287 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05029401 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2021 | DemeRx IB, Inc., ERT Clinical, MAC Clinical Research |
| NCT04003948 | Phase 2 | Oct 1, 2019 | International Center for Ethnobotanical Education, Research, and Service, Multidisciplinary Association for Psychedelic Studies, Rovira i Virgili University, Universidad Autonoma de Madrid, University of Sao Paulo |
| NCT03380728 | Phase 2 | Aug 31, 2018 | Conselho Nacional de Desenvolvimento Científico e Tecnológico, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), University of Sao Paulo |
Showing 3 of 3 trials
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Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Sao Paulo | Academic/Hospital | 2 | 1 | 1 | 2018 |
| Conselho Nacional de Desenvolvimento Científico e Tecnológico | Government | 1 | 0 | 1 | 2018 |
| Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | Government | 1 | 0 | 1 | 2018 |
| DemeRx IB, Inc. | For profit | 1 | 1 | 1 | 2021 |
| ERT Clinical | For profit | 1 | 0 | 1 | 2021 |
| International Center for Ethnobotanical Education, Research, and Service | Academic/Hospital | 1 | 1 | 1 | 2019 |
| MAC Clinical Research | For profit | 1 | 0 | 1 | 2021 |
| Multidisciplinary Association for Psychedelic Studies | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Rovira i Virgili University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Universidad Autonoma de Madrid | Academic/Hospital | 1 | 0 | 1 | 2019 |
10 organizations
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