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trimetazidine

Small moleculeexperimental

Trimetazidine is a drug sold under many brand names for angina pectoris. Trimetazidine is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier (France). It is an anti-ischemic (antianginal) metabolic agent of the fatty acid oxidation inhibitor class, meaning that it improves the heart muscle's ability to use glucose as a fuel by inhibiting its use of fatty acid metabolism. It has become controversial for its use as a performance-enhancing drug, with several scandals involving its use erupting at successive Olympic games. — Wikipedia

Clinical trial activity

33 trials · 45 clinical orgs · 0 marketing orgs

Phase 1
4
Phase 2
13
Phase 3
6
Phase 4
9

Earliest trial started Feb 1, 1999 (NCT00282360)

Timeline

2010s

  1. Jan 1, 2012

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2017

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2017

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

COc1ccc(CN2CCNCC2)c(OC)c1OC
Mol. weight
266.34 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride
  • 1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride
  • trimetazidine
  • trimetazidine
  • trimetazidine
  • trimetazidine
  • trimetazidine
  • trimetazidine
  • trimetazidine
  • trimetazidine
  • trimetazidine dihydrochloride
  • trimetazidine dihydrochloride
  • trimetazidine dihydrochloride
  • trimetazidine hcl
  • trimetazidine hcl
  • trimetazidine hcl
  • trimetazidine hydrochloride
  • vastarel
  • vastarel
  • vastarel
  • vastarel mr

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06656442Phase 3Sep 1, 2024Ain Shams University
NCT06459193Phase 1/Phase 2 (Phase 2)Jun 23, 2024Minia University
NCT06140953Phase 2Dec 10, 2023Beni Suef University, October 6 University
NCT06012708Phase 1Sep 30, 2023—
NCT05540184Phase 4Sep 30, 2022Beni Suef University, Cairo University
NCT05556005Phase 2Sep 18, 2022Ain Shams University
NCT05147194Phase 2Jan 1, 2022Huazhong University of Science and Technology
NCT05633563Phase 4Oct 1, 2021Aarhus University
NCT04788745Phase 2Jun 29, 2021FightMND, Julius Clinical, The Netherlands, Royal Brisbane & Women's Hospital, University of London, University of Queensland, Utrecht University
NCT04939857Phase 2/Phase 3 (Phase 3)Jun 25, 2021Peking University
NCT04702906N/AFeb 28, 2021Tanta University
NCT07074834N/AFeb 1, 2021Shiyan City Renmin Hospital
NCT04760821Phase 2Dec 10, 2020Government of Brazil, University of Sao Paulo
NCT03809273Phase 4Jun 25, 2019China Medical University
NCT04661709Phase 4Jun 10, 2019China Academy of Chinese Medical Sciences, Government of China, National Natural Science Foundation of China
NCT03887013Phase 4Mar 25, 2019Chinese Academy of Medical Sciences
NCT03737448Phase 1Nov 28, 2018Martin Pharmaceuticals
NCT03715582Phase 3Oct 1, 2018University of Sao Paulo
NCT03504202N/AOct 1, 2018Huazhong University of Science and Technology
NCT03603249Phase 2Jul 1, 2018University of The West Indies
Showing 20 of 33 trials
Page 1 / 2

Organizations

Research & Development (45)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
China Academy of Chinese Medical SciencesAcademic/Hospital3312017
Ain Shams UniversityAcademic/Hospital2222022
Anyang Regional HospitalAcademic/Hospital2012017
Beni Suef UniversityAcademic/Hospital2122022
First People's Hospital of ShangqiuAcademic/Hospital2012017
Huazhong University of Science and TechnologyAcademic/Hospital2222018
Jiaozuo third people's hospitalAcademic/Hospital2012017
Luoyang Central HospitalAcademic/Hospital2012017
Nanyang Central HospitalAcademic/Hospital2012017
University of LondonAcademic/Hospital2112012
University of Sao PauloAcademic/Hospital2122018
Xinxiang Medical UniversityAcademic/Hospital2012017
Zhengzhou UniversityAcademic/Hospital2212017
Aarhus UniversityAcademic/Hospital1112021
British Heart FoundationAcademic/Hospital1012012
Cairo UniversityAcademic/Hospital1012022
China Medical UniversityAcademic/Hospital1112019
Chinese Academy of Medical SciencesAcademic/Hospital1112019
Clinical Hospital Center ZemunAcademic/Hospital1112014
Dalian Medical UniversityAcademic/Hospital1112017
45 organizations
Page 1 / 3