sm08502
Small moleculeexperimental
Clinical trial activity
6 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Nov 6, 2017 (NCT03355066)
Timeline
Indications
Studied for
- Carcinoma, Non-Small-Cell Lung · Phase 1
- Colorectal Neoplasms · Phase 1
- Fallopian Tube Neoplasms · Phase 1
- Hamartoma · Phase 1
- Leukemia, Myeloid, Acute · Phase 1
- Myelodysplastic Syndromes · Phase 1
- Neoplasms · Phase 1
- Ovarian Neoplasms · Phase 1
- Prostatic Neoplasms, Castration-Resistant · Phase 1
- Sarcoma · Phase 2
- Small Cell Lung Carcinoma · Phase 1/Phase 2
Mechanism of action
- Dual specificity protein kinase CLK2INHIBITOR
CLK2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1- Mol. weight
- 427.51 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4784318 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06856499 | Phase 1 | Dec 31, 2025 | National Cancer Institute (NCI), National Institutes of Health (NIH), University of Colorado, Denver |
| NCT07155200 | Phase 1/Phase 2 (Phase 2) | Dec 31, 2025 | Biosplice Therapeutics, Washington University in St. Louis |
| NCT07032285 | Phase 2 | Jan 15, 2025 | Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas, Biosplice Therapeutics |
| NCT06484062 | Phase 1 | Dec 6, 2024 | Harvard University, National Cancer Institute (NCI) |
| NCT05084859 | Phase 1 | Nov 3, 2021 | Biosplice Therapeutics |
| NCT03355066 | Phase 1 | Nov 6, 2017 | Biosplice Therapeutics |
Showing 6 of 6 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Biosplice Therapeutics | For profit | 4 | 2 | 2 | 2017 |
| National Cancer Institute (NCI) | Government | 2 | 1 | 1 | 2024 |
| Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2024 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2025 |
| University of Colorado, Denver | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Washington University in St. Louis | Academic/Hospital | 1 | 1 | 1 | 2025 |
7 organizations
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