bi 907828
Small moleculeexperimental
Clinical trial activity
11 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
5
Phase 3
3
Phase 4
0
Earliest trial started May 21, 2018 (NCT03449381)
Timeline
Indications
Studied for
- Biliary Tract Neoplasms · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Colorectal Neoplasms · Phase 2
- Glioblastoma · Phase 1
- Liposarcoma · Phase 3
- Lung Neoplasms · Phase 2
- Myxosarcoma · Phase 3
- Neoplasms · Phase 2
- Pancreatic Neoplasms · Phase 2
- Sarcoma · Phase 3
- Triple Negative Breast Neoplasms · Phase 2
- Urinary Bladder Neoplasms · Phase 2
Mechanism of action
- p53-binding protein Mdm-2ANTAGONIST
MDM2 antagonist
Chemistry & pharmacology
Loading structure…
SMILES
Cc1c(C(=O)O)ccc2c3n(nc12)[C@@H]1[C@H](C3)N(CC2CC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F- Mol. weight
- 591.47 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL5314455 ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06619509 | Phase 2 | Dec 4, 2024 | Boehringer Ingelheim |
| NCT06370871 | Phase 3 | Jun 27, 2024 | Boehringer Ingelheim |
| NCT06084689 | Phase 2 | Jan 1, 2024 | Boehringer Ingelheim, Institut Bergonié |
| NCT06058793 | Phase 3 | Dec 12, 2023 | Boehringer Ingelheim |
| NCT05512377 | Phase 2 | Nov 25, 2022 | Boehringer Ingelheim |
| NCT05613036 | Phase 1 | Nov 8, 2022 | Boehringer Ingelheim |
| NCT05376800 | Phase 1 | Jul 28, 2022 | Boehringer Ingelheim |
| NCT05372367 | Phase 1 | Jun 30, 2022 | Boehringer Ingelheim |
| NCT05218499 | Phase 2/Phase 3 (Phase 3) | Mar 25, 2022 | Boehringer Ingelheim |
| NCT03964233 | Phase 1 | Jun 11, 2019 | Boehringer Ingelheim |
| NCT03449381 | Phase 1 | May 21, 2018 | Boehringer Ingelheim |
Showing 11 of 11 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Boehringer Ingelheim | For profit | 11 | 10 | 3 | 2018 |
| Institut Bergonié | Academic/Hospital | 1 | 1 | 1 | 2024 |
2 organizations
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