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benzathine penicillin

Small moleculeexperimental

Clemizole is a drug in clinical development for the treatment of hepatitis C virus (HCV) infection. Clemizole is a novel inhibitor of TRPC5 channels. Clemizole is an H1 antagonist. Clemizole, an antihistamine drug that was once widely used for treatment of allergic disease, was recently discovered to be a potent inhibitor (IC50, 24 nM) of the interaction between an HCV protein (NS4B) and HCV RNA. Although clemizole was widely used during the 1950s and 1960s, this was before contemporary regulatory requirements were established for new drug development, and there is very minimal information about its pharmacokinetics and metabolism. — NCATS

Clinical trial activity

24 trials · 59 clinical orgs · 0 marketing orgs

Phase 1
4
Phase 2
11
Phase 3
4
Phase 4
6

Earliest trial started Aug 1, 2001 (NCT01156740)

Timeline

2000s

  1. Jan 1, 2009

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2017

    Earliest Phase 2 Sponsor(trial)

2020s

  1. Jan 1, 2021

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

ClC1=CC=C(CN2C(CN3CCCC3)=NC4=C2C=CC=C4)C=C1
Mol. weight
325.835 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • al-20
  • al-20
  • benzatine
  • clemizole
  • clemizole
  • clemizole
  • clemizole
  • clemizole
  • clemizole hcl
  • clemizole hcl
  • clemizole hcl
  • clemizole hydrochloride
  • clemizole hydrochloride
  • clemizole hydrochloride
  • lergopenin
  • penicillin g, benzathine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07189208Phase 2Nov 1, 2025National Institute of Allergy and Infectious Diseases (NIAID), University of California, Los Angeles
NCT06921213Phase 2Oct 1, 2025Chiangmai University, Medical Research Council, Murdoch University, National University of Ireland, Stellenbosch University, University of London, University of Sydney, Wellcome Trust
NCT06707194Phase 4Mar 1, 2025Southern Medical University
NCT06877351Phase 3Aug 14, 2024University of Buenos Aires
NCT06069141N/AOct 31, 2023Chiayi Christian Hospital, Chimei Medical Center, China Medical University, Far Eastern Memorial Hospital, Kaohsiung Medical University, National Cheng Kung University, National Taiwan University, Taipei Veteran General hospital, Taoyuan General Hospital
NCT06192277N/AOct 6, 2023Northern Ontario School of Medicine
NCT05693545Phase 2Sep 1, 2023Uganda Heart Institute, University of Cincinnati
NCT05548426Early Phase 1 (Phase 1)Apr 30, 2023Cayetano Heredia University, University of Southern California, University of Texas at Houston
NCT05980871Phase 4Mar 10, 2023National Taiwan University
NCT05137119Phase 4Dec 1, 2021Berry Consultants, Menzies School of Health Research, Nanyang Technological University, Queensland University of Technology, Telethon Kids Institute, The Peter Doherty Institute, University of Melbourne, University of Queensland, University of Toronto
NCT04838717Phase 3Nov 30, 2021Assistance Publique - Hôpitaux de Paris
NCT05094154Phase 4Nov 10, 2021Vanderbilt University
NCT05069974Phase 3Oct 14, 2021FUNDACIÓN FLS DE LUCHA CONTRA EL SIDA, LAS ENFERMEDADES INFECCIOSAS Y LA PROMOCIÓN DE LA SALUD Y LA CIENCIA
NCT06907316Phase 4Jul 13, 2021Bulovka Hospital, Orebro University
NCT04958122Phase 3Jun 20, 2021AIDS Healthcare Foundation, Cayetano Heredia University, University of Southern California
NCT04454229N/AJun 1, 2021Austin Health, McGill University
NCT03752112Phase 1/Phase 2 (Phase 2)Apr 1, 2019World Health Organization
NCT03637660Phase 4Oct 18, 2018National Institute of Allergy and Infectious Diseases (NIAID)
NCT03660488Phase 2Sep 30, 2018AIDS Healthcare Foundation, University of California, Los Angeles
NCT03612557Phase 1Aug 20, 2018Pfizer
Showing 20 of 24 trials
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Organizations

Research & Development (59)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
AIDS Healthcare FoundationAcademic/Hospital2022018
Cayetano Heredia UniversityAcademic/Hospital2022021
Eiger BioPharmaceuticalsFor profit2222009
Murdoch UniversityAcademic/Hospital2012018
National Institute of Allergy and Infectious Diseases (NIAID)Government2122018
National Taiwan UniversityAcademic/Hospital2222023
University of California, Los AngelesAcademic/Hospital2212018
University of Southern CaliforniaAcademic/Hospital2222021
World Health OrganizationGovernment2122001
Assistance Publique - Hôpitaux de ParisAcademic/Hospital1112021
Austin HealthAcademic/Hospital1112021
Berry ConsultantsFor profit1012021
Bulovka HospitalAcademic/Hospital1112021
Cairo UniversityAcademic/Hospital1012001
Chiangmai UniversityAcademic/Hospital1012025
Chiayi Christian HospitalAcademic/Hospital1012023
Children's National Medical CenterAcademic/Hospital1112018
Chimei Medical CenterAcademic/Hospital1012023
China Medical UniversityAcademic/Hospital1012023
Far Eastern Memorial HospitalAcademic/Hospital1012023
59 organizations
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