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inosine

Small moleculeexperimental

Inosine pranobex is an antiviral drug that is a combination of inosine and dimepranol acedoben in a ratio of 1 to 3. It is used primarily in European countries, especially as a treatment for acute viral infections, such as the common cold. — Wikipedia

Clinical trial activity

33 trials · 35 clinical orgs · 0 marketing orgs

Phase 1
7
Phase 2
14
Phase 3
11
Phase 4
1

Earliest trial started Nov 2, 1999 (NCT00002297)

Timeline

1990s

  1. Jan 1, 1999

    Earliest Phase 1 Sponsor(trial)

2000s

  1. Jan 1, 2002

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2016

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetSupplementation

    supplementation

Chemistry & pharmacology

Loading structure…

SMILES

CC(O)CN(C)C.CC(O)CN(C)C.CC(O)CN(C)C.OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3C(=O)NC=Nc23
Mol. weight
577.72 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 9-beta-d-ribofuranosylhypoxanthine
  • beta-inosine
  • beta-inosine
  • hypoxanthine ribonucleoside
  • hypoxanthine riboside
  • hypoxanthosine
  • hypoxanthosine
  • hypoxanthosine
  • iad
  • iad
  • imunovir
  • imunovir
  • ino
  • ino
  • inosina
  • inosina
  • inosine
  • inosine
  • inosine
  • inosine
  • inosine
  • inosine
  • inosine
  • inosine
  • inosine-2-hydroxypropyldimethylammonium 4-acetamidobenzoate (1:3)
  • inosine-2-hydroxypropyldimethylammonium 4-acetamidobenzoate (1:3)
  • inosine acedobene dimepranol
  • inosine acedobene dimepranol
  • inosine pranobex
  • inosine pranobex
  • inosine pranobex
  • inosine pranobex
  • inosine pranobex
  • inosine pranobex
  • inosinum
  • inosinum
  • inosiplex
  • inosiplex
  • isoprinosin
  • isoprinosine
  • isoprinosine
  • isoprinosine
  • methisoprinol
  • methisoprinol
  • nos
  • nos
  • oxiamin
  • oxiamin
  • oxiamin
  • ribonosine
  • ribonosine
  • ribonosine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07170475Phase 1Jun 27, 2025Fujita Health University
NCT06355024Phase 2Apr 10, 2024Fudan University
NCT06183242Phase 2/Phase 3 (Phase 3)May 27, 2023Polysan, Ltd.
NCT05935787Phase 3Mar 23, 2023Polysan, Ltd.
NCT04890808N/ASep 30, 2021Superfical Siderosis Research Alliance, Superficial Siderosis Research Alliance Inc.
NCT04631484Phase 3Oct 8, 2020Polysan, Ltd.
NCT04476238N/ASep 1, 2020University of Basel
NCT04649203Phase 3Jun 29, 2020Polysan, Ltd.
NCT04360122Phase 3May 20, 2020Ain Shams University
NCT04383717Phase 3May 5, 2020Cairo University
NCT05809336Phase 2/Phase 3 (Phase 3)May 1, 2019Capital Medical University
NCT03883334Phase 4Feb 28, 2019Universidad San Francisco de Quito
NCT03403309Phase 2Feb 1, 2018Yonsei University
NCT03168711Phase 2Jul 1, 2017Harvard University, The Salah Foundation
NCT03849664Phase 3Jun 2, 2017Polysan, Ltd., St. Petersburg Research Institute of Emergency Medicine
NCT03416062Phase 3Apr 3, 2017Avicenna Medical Center, BioEq, Irkutsk Regional Clinical Hospital, Petrov Research Institute of Oncology, Polysan, Ltd., Regional Clinical oncologic center, Omsk region, State Budgetary Health Care Institution "City Hospital № 26", St. Petersburg Mechnikov State Medical Academy
NCT03418935Phase 3Apr 3, 2017BioEq, Irkutsk Regional Clinical Hospital, Leningrad Regional Clinical Hospital, Polysan, Ltd., State Budgetary Health Care Institution "City Hospital № 26", St. Petersburg Mechnikov State Medical Academy
NCT02642393Phase 3Jun 1, 2016Harvard University, Michael J. Fox Foundation for Parkinson's Research, National Institute of Neurological Disorders and Stroke (NINDS), The Parkinson Study Group, University of Rochester
NCT02614469Phase 1Mar 1, 2015Harvard University, Michael J. Fox Foundation for Parkinson's Research, The Parkinson Alliance
NCT02288091Phase 1Jan 1, 2015Harvard University, The Salah Foundation
Showing 20 of 33 trials
Page 1 / 2

Organizations

Research & Development (35)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Polysan, Ltd.For profit7712017
Newport Pharmaceuticals InternationalFor profit6611999
Harvard UniversityAcademic/Hospital5432009
Michael J. Fox Foundation for Parkinson's ResearchAcademic/Hospital3032009
Washington University in St. LouisAcademic/Hospital3312009
BioEqFor profit2012017
Irkutsk Regional Clinical HospitalAcademic/Hospital2012017
State Budgetary Health Care Institution "City Hospital № 26"Academic/Hospital2012017
St. Petersburg Mechnikov State Medical AcademyAcademic/Hospital2012017
The Parkinson Study GroupAcademic/Hospital2122009
The Salah FoundationAcademic/Hospital2022015
University of RochesterAcademic/Hospital2022009
Ain Shams UniversityAcademic/Hospital1112020
Avicenna Medical CenterAcademic/Hospital1012017
Cairo UniversityAcademic/Hospital1112020
Capital Medical UniversityAcademic/Hospital1112019
Doris Duke Charitable FoundationAcademic/Hospital1012014
Fudan UniversityAcademic/Hospital1112024
Fujita Health UniversityAcademic/Hospital1112025
Leningrad Regional Clinical HospitalAcademic/Hospital1012017
35 organizations
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