serotonin
Small moleculeexperimental
Serotonin, also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, memory, and physiological processes such as vomiting and vasoconstriction. In the CNS, serotonin regulates mood, appetite, and sleep. — Wikipedia
Clinical trial activity
3 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
1
Earliest trial started May 1, 2005 (NCT00227136)
Timeline
2000s
- Jan 1, 2005
Earliest Phase 3 Sponsor(trial)
Indications
Mechanism of action
- Serotonin 4 (5-HT4) receptorAGONIST
HTR4 agonist
Chemistry & pharmacology
Loading structure…
SMILES
NCCc1c[nH]c2ccc(O)cc12- Mol. weight
- 176.22 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSerotonin ↗
- ChEMBLCHEMBL39 ↗
Also known as
- 5-hydroxy-tryptamine
- 5-hydroxy-tryptamine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06740188 | Phase 4 | Jan 1, 2025 | Huazhong University of Science and Technology |
| NCT03576053 | N/A | Jul 1, 2018 | Aalborg University |
| NCT00227136 | Phase 3 | May 1, 2005 | University of Western Ontario |
Showing 3 of 3 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aalborg University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Western Ontario | Academic/Hospital | 1 | 1 | 1 | 2005 |
3 organizations
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