rutin

Botanicalexperimental

Rutin, also called rutoside, is the glycoside flavonoid found in a certain fruits and vegetables. Most rutine-rich foods are capers, olives, buckwheat (whole grain flour), asparagus, raspberry.In a clinical trial, rutin was found to aid control of intraocular pressure in patients with primary open angle glaucoma. As a component of dietary supplement Phlogenzym, rutin is used for treatment of osteoarthritis. Rutin is also used for treatment of post-surgical swelling of the arm after breast cancer surgery. Traditionally, rutin is used to prevent mucositis due to cancer treatment, to treat blood vessel disease such as varicose veins, bleeding, hemorrhoids. — NCATS

Clinical trial activity

28 trials · 43 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Aug 1, 1996 (NCT00003365)

Timeline

2010s

Jan 1, 2010
Earliest Phase 3 Sponsor(trial)
Jan 1, 2011
Earliest Phase 2 Sponsor(trial)
Jan 1, 2012
Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Unspecified targetUnclear
unclear

Chemistry & pharmacology

Loading structure…

SMILES

C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](OC3=C(OC4=C(C3=O)C(O)=CC(O)=C4)C5=CC=C(O)C(O)=C5)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O

Mol. weight: 610.5175 g/mol
Lipinski Ro5: 3 violation(s)
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No

Oral

Parenteral

Topical

Sources

Also known as

2-(3,4-bis(2-hydroxyethoxy)phenyl)-3-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl)oxy)-5-hydroxy-7-(2-hydroxy ethoxy)-4h-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-3-(beta-d-glucofuranosyloxy)-5,7-dihydroxy-4h-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-chromen-3-yl 6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-chromen-3-yl 6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranoside
3',4',7-trihydroxyethylrutin
3',4',7-tris(o-(2- hydroxyethyl))rutin
4h-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(beta-d-glucofuranosyloxy)-5,7-dihydroxy
flavone, 3,3',4',5,7-pentahydroxy-, 3-beta-d-glucofuranoside
flavonoid
flavonoid
flavonoid
flavonoids
globulariacitrin
globularicitrin
isoquercetin
isoquercetin
isoquercetin
isoquercitin
isoquercitrin
isoquercitrin
isoquercitrin
isoquercitroside
isotrifoliin
myrticalorin
myrticolorin
nsc-115918
nsc-115918
oxerutin
paroven
phytomelin
phytomelin
posorutin
posorutin
quercetin 3-(beta-d-glucofuranoside)
quercetin-3-glucoside
quercetin 3-o-beta-d-glucofuranoside
quercetin-3-o-beta-glucoside
quercetin 3-o-glucopyranoside
quercetin 3-o-glucopyranoside
quercetin-3-o-glucoside
quercetin-3-o-glucoside
quercetin-3-o-glucoside
quercetin 3-o-rutinoside
quercetin 3-rutinoside
quercetin-3-rutinoside
quercetin-3-rutinoside
quercetin rutinoside
relvene
rhéoflux
rutabion
rutin
rutin
rutin
rutin
rutin
rutin
rutin
rutine
rutinic acid
rutoside
rutoside
rutoside
rutoside
rutoside
ruven
sophorin
teboven
thr
thr
trifoliin
trifoliin a
trioxyethylrutin
trioxyethylrutin
trioxyethylrutin
troxerutin
troxerutin
troxerutin
troxerutin
troxerutin
troxerutin
troxerutin
troxerutin
troxerutine
troxérutine mazal
troxerutin-ratiopharm
troxevazin
troxeven
vastribil
vastribil
veinamitol
veinamitol
veniten
veniten retard
venorutin
venoruton
venoruton
venoruton p4
veno sl
venotrulan trox
vitamin p4
vitamin p4
vitamin p4
z-6000
z-6000

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT06298383	N/A	Mar 15, 2024	Cairo University, Egyptian Russian University
NCT04283591	N/A	Aug 1, 2019	Istanbul Physical Medicine Rehabilitation Training and Research Hospital
NCT04161872	Phase 4	Oct 1, 2018	University of Pavia
NCT03569930	Phase 4	May 1, 2018	University of Roma La Sapienza
NCT03437902	Phase 2/Phase 3 (Phase 3)	Feb 24, 2018	Ain Shams University
NCT02782455	Phase 4	Dec 1, 2016	Services Hospital, Lahore, Services Institute of Medical Sciences, Pakistan
NCT02907320	Phase 2	Dec 1, 2016	Eurotrials Brasil Consultores Cientificos Ltda, Pierre Fabre
NCT02446795	Phase 1/Phase 2 (Phase 2)	Nov 1, 2016	Clinical Research Technology S.r.l., Oncotech, Quercegen Pharmaceuticals
NCT02866448	N/A	Aug 1, 2016	Biotechnology and Biological Sciences Research Council, Quercegen Pharmaceuticals, University of Reading
NCT02871596	N/A	Aug 1, 2016	Pharmanex, Utah State University
NCT02818699	N/A	Aug 1, 2016	Tufts University, United States Department of Agriculture
NCT02552888	Phase 2	Mar 1, 2016	Tulane University
NCT03004742	N/A	Aug 1, 2015	Appalachian State University, Reoxcyn Discoveries Group
NCT00609310	Phase 2	May 1, 2015	Technical University of Dresden, University of Heidelberg
NCT02195232	Phase 2/Phase 3 (Phase 3)	Jan 1, 2015	Harvard University, National Heart, Lung, and Blood Institute (NHLBI), Quercegen Pharmaceuticals
NCT01922869	N/A	Jul 1, 2013	University of East Anglia, University of Washington
NCT01848210	Phase 4	May 1, 2013	Takeda
NCT01722669	Early Phase 1 (Phase 1)	May 1, 2012	Harvard University
NCT01530893	N/A	Feb 1, 2012	University of East Anglia
NCT01847521	Phase 2	Dec 1, 2011	University of Athens

Showing 20 of 28 trials

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Organizations

Research & Development (43)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Quercegen Pharmaceuticals	For profit	3	0	3	2015
University of East Anglia	Academic/Hospital	3	3	1	2008
Harvard University	Academic/Hospital	2	2	2	2012
University of Reading	Academic/Hospital	2	2	1	2009
University of Roma La Sapienza	Academic/Hospital	2	2	2	2010
Abbott	For profit	1	1	1	2005
Ain Shams University	Academic/Hospital	1	1	1	2018
Appalachian State University	Academic/Hospital	1	1	1	2015
Azidus	For profit	1	1	1	2010
Barry Callebaut	For profit	1	0	1	2008
Biotechnology and Biological Sciences Research Council	Academic/Hospital	1	0	1	2016
Cairo University	Academic/Hospital	1	1	1	2024
Clinical Research Technology S.r.l.	For profit	1	0	1	2016
Diabetes UK	Academic/Hospital	1	0	1	2008
Egyptian Russian University	Academic/Hospital	1	0	1	2024
Eurotrials Brasil Consultores Cientificos Ltda	For profit	1	0	1	2016
Frutarom Netherlands B.V.	For profit	1	0	1	2008
Istanbul Physical Medicine Rehabilitation Training and Research Hospital	Academic/Hospital	1	1	1	2019
LAL Clinical Reseach e Development Ltda	Academic/Hospital	1	0	1	2010
National Cancer Institute (NCI)	Government	1	0	1	1996

43 organizations

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