tinostamustine
Small moleculeexperimental
Clinical trial activity
7 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Mar 1, 2016 (NCT02576496)
Timeline
2010s
- Jan 1, 2016
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Endometrial Neoplasms · Phase 1/Phase 2
- Glioblastoma · Phase 1
- Gliosarcoma · Phase 1
- Hematologic Neoplasms · Phase 1
- Hodgkin Disease · Phase 1
- Lymphoma, Large B-Cell, Diffuse · Phase 1
- Lymphoma, T-Cell, Cutaneous · Phase 1
- Melanoma · Phase 1
- Multiple Myeloma · Phase 1/Phase 2
- Ovarian Neoplasms · Phase 1/Phase 2
- Sarcoma · Phase 1/Phase 2
- Small Cell Lung Carcinoma · Phase 1/Phase 2
- Triple Negative Breast Neoplasms · Phase 1/Phase 2
Mechanism of action
- DNACROSS-LINKING AGENT
DNA cross-linking agent
Chemistry & pharmacology
Loading structure…
SMILES
Cn1c(CCCCCCC(=O)NO)nc2cc(N(CCCl)CCCl)ccc21- Mol. weight
- 415.37 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3989941 ↗
Also known as
- edo-s101
- edo-s101
- tinostamustine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05432375 | Early Phase 1 (Phase 1) | Jul 1, 2022 | Mundipharma |
| NCT03903458 | Phase 1 | Mar 7, 2019 | Cantonal Hospital of St. Gallen |
| NCT04279938 | Phase 1 | Sep 30, 2018 | Merck, Mundipharma, Royal Marsden Hospital NHS Trust |
| NCT03687125 | Phase 1/Phase 2 (Phase 2) | Sep 19, 2018 | Mundipharma |
| NCT03452930 | Phase 1 | Aug 13, 2018 | Mundipharma, University of Texas at Houston |
| NCT03345485 | Phase 1/Phase 2 (Phase 2) | Oct 6, 2017 | Mundipharma, Stanford University |
| NCT02576496 | Phase 1 | Mar 1, 2016 | Columbia University, Mundipharma |
Showing 7 of 7 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Mundipharma | For profit | 6 | 4 | 2 | 2016 |
| Cantonal Hospital of St. Gallen | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Columbia University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Merck | For profit | 1 | 0 | 1 | 2018 |
| Royal Marsden Hospital NHS Trust | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Stanford University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Texas at Houston | Academic/Hospital | 1 | 1 | 1 | 2018 |
7 organizations
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