131i-lipiodol
Trade name: Lipiodol
Small moleculeexperimental
Iodized oil, also known as ethiodized oil, brand name Lipiodol, is a medication derived from poppyseed oil and iodine. When given by injection, it is a radio-opaque contrast agent that is used to outline structures in radiological investigations. When given orally or by intramuscular injection once or twice a year, it prevents endemic goitre in remote communities. It has an additional use in gastric variceal obliteration as a dilutant that does not affect polymerization of cyanoacrylate. — Wikipedia
Clinical trial activity
38 trials · 73 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
19
Phase 3
14
Phase 4
7
Earliest trial started Jul 1, 2005 (NCT00116454)
Timeline
Indications
Approved for
Studied for
- Arteriovenous Malformations · Phase 4
- Carcinoma, Hepatocellular · Phase 4
- Colorectal Neoplasms · Phase 4
- Hemangioendothelioma · Phase 4
- Hemangiosarcoma · Phase 4
- Hepatitis, Viral, Human · Phase 3
- Histiocytic Sarcoma · Phase 4
- Infertility · Phase 4
- Infertility, Female · Phase 4
- Liver Cirrhosis · Phase 3
- Liver Neoplasms · Phase 3
- Lung Diseases · Phase 3
- Lung Neoplasms · Phase 1
- Neoplasm Metastasis · Phase 3
- Neoplasm Recurrence, Local · Phase 3
- Neoplasms · Phase 3
- Neoplastic Cells, Circulating · Phase 4
- Neuroendocrine Tumors · Phase 3
- Osteoarthritis, Knee · Phase 1
- Pancreatic Neoplasms · Phase 1
- Pediatrics · Phase 3
- Recurrence · Phase 3
Mechanism of action
- Unspecified targetRadiodepletion
radiodepletion
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaIodized oil ↗
- WikipediaLipiodol ↗
Also known as
- 131i-lipiodol
- lipiodol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05842174 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2023 | Department of Veteran Affairs |
| NCT05435014 | Phase 1/Phase 2 (Phase 2) | Sep 13, 2022 | T-ACE Medical Co., Ltd |
| NCT04733092 | Phase 1 | Mar 3, 2021 | Assistance Publique - Hôpitaux de Paris, Guerbet, Hôpital Européen Georges-Pompidou |
| NCT04379973 | Phase 4 | Nov 1, 2020 | Katholieke Universiteit Leuven, University of Antwerp |
| NCT04178642 | Phase 2 | Jan 31, 2020 | University of Montpellier |
| NCT04200417 | Phase 1 | Dec 13, 2019 | Memorial Sloan-Kettering Cancer Center |
| NCT04048317 | Early Phase 1 (Phase 1) | Sep 1, 2019 | Assiut University |
| NCT05608590 | Phase 4 | Aug 22, 2019 | Free University of Amsterdam, ZonMw: The Netherlands Organisation for Health Research and Development |
| NCT03865563 | Phase 1 | Jul 31, 2019 | Johns Hopkins University |
| NCT03604549 | Phase 4 | Oct 31, 2018 | Guerbet, Pennsylvania State University |
| NCT03617029 | N/A | Sep 30, 2018 | National Taiwan University |
| NCT03727633 | Phase 2 | Jun 26, 2018 | Guerbet, University of Montpellier |
| NCT03542331 | Phase 3 | Mar 1, 2018 | Free University of Brussels |
| NCT03338647 | Phase 3 | Oct 26, 2017 | Aarhus University, International Atomic Energy Agency |
| NCT03192644 | Phase 3 | Jul 1, 2017 | Sun Yat-Sen University |
| NCT02625389 | Phase 4 | Mar 1, 2017 | Guerbet |
| NCT02971345 | Phase 3 | Jan 1, 2017 | Anhui College of Traditional Chinese Medicine, Central South University, Changhai Hospital, China Medical University, Chinese Academy of Medical Sciences, Fudan University, Fujian Medical University, Harbin Medical University, Huazhong University of Science and Technology, Jiangsu University, Jiao Tong University, LanZhou University, Lishui Country People's Hospital, Nanjing Medical University, Second People's Hospital of Yibin, Shanxi Medical University, Soochow University, Southern Medical University, Tengzhou Central People's Hospital, Xiamen University, Yancheng Third People's Hospital, Zhejiang University, Zhengzhou University |
| NCT02964260 | N/A | May 1, 2016 | Shantou University, Sun Yat-Sen University |
| NCT02724540 | Phase 3 | Mar 1, 2016 | University of Pennsylvania |
| NCT02762266 | Phase 3 | Feb 27, 2016 | National Cancer Institute (NCI), Stanford University |
Showing 20 of 38 trials
Page 1 / 2
Organizations
Research & Development (73)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Fudan University | Academic/Hospital | 6 | 5 | 3 | 2010 |
| Guerbet | For profit | 5 | 1 | 3 | 2013 |
| Sun Yat-Sen University | Academic/Hospital | 5 | 4 | 2 | 2013 |
| Eastern Hepatobiliary Surgery Hospital | Academic/Hospital | 3 | 1 | 2 | 2009 |
| Shantou University | Academic/Hospital | 3 | 1 | 2 | 2013 |
| Aarhus University | Academic/Hospital | 2 | 2 | 2 | 2008 |
| Anhui College of Traditional Chinese Medicine | Academic/Hospital | 2 | 0 | 1 | 2015 |
| Central South University | Academic/Hospital | 2 | 0 | 1 | 2015 |
| Changhai Hospital | Academic/Hospital | 2 | 0 | 1 | 2015 |
| Harbin Medical University | Academic/Hospital | 2 | 0 | 1 | 2015 |
| Huazhong University of Science and Technology | Academic/Hospital | 2 | 0 | 1 | 2015 |
| LanZhou University | Academic/Hospital | 2 | 0 | 1 | 2015 |
| Nanjing Medical University | Academic/Hospital | 2 | 0 | 1 | 2015 |
| Southern Medical University | Academic/Hospital | 2 | 0 | 1 | 2015 |
| University of Montpellier | Academic/Hospital | 2 | 2 | 1 | 2018 |
| University of Paris | Academic/Hospital | 2 | 1 | 1 | 2005 |
| Xiamen University | Academic/Hospital | 2 | 0 | 2 | 2013 |
| Zhejiang University | Academic/Hospital | 2 | 0 | 1 | 2015 |
| Anhui Medical University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Assistance Publique - Hôpitaux de Paris | Academic/Hospital | 1 | 1 | 1 | 2021 |
73 organizations
Page 1 / 4