novobiocin

Trade name: albamycin

Small moleculeapproved

Approved

Sep 4, 1964

Novobiocin, also known as albamycin, is an aminocoumarin antibiotic that is produced by the actinomycete Streptomyces niveus, which has recently been identified as a subjective synonym for S. spheroides a member of the class Actinomycetia. Other aminocoumarin antibiotics include clorobiocin and coumermycin A1. Novobiocin was first reported in the mid-1950s. — Wikipedia

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1960s

  1. Sep 4, 1964

    Upjohn — Earliest FDA Approval

  2. Sep 4, 1964

    Pharmacia & Upjohn — NDA Secondary Org

  3. Sep 4, 1964

    Upjohn — NDA Organization

Indications

Mechanism of action

Approval history

  • approvedSep 4, 1964

Chemistry & pharmacology

Loading structure…

SMILES

CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C
Mol. weight
612.63 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • albamycin
  • albamycin
  • albamycin
  • albamycin
  • albamycin t
  • cardelmycin
  • cathomycin
  • cathomycin
  • cathomycin
  • inamycin
  • n-{7-[(3-o-carbamoyl-6-deoxy-5-methyl-4-o-methyl-beta-d-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2h-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide
  • novobiocin
  • novobiocin
  • novobiocin
  • novobiocin
  • novobiocin
  • novobiocin
  • novobiocin
  • novobiocin
  • novobiocin
  • novobiocina
  • novobiocina
  • novobiocin calcium
  • novobiocine
  • novobiocine
  • novobiocin sodium
  • novobiocin sodium
  • novobiocin sodium
  • novobiocin sodium
  • novobiocin sodium salt
  • novobiocinum
  • novobiocinum
  • spheromycin
  • spheromycin
  • streptonivicin

Organizations

Marketing (2)

OrganizationOrg typeRelationshipDate
Pharmacia & UpjohnFor profitNDA2Sep 4, 1964
UpjohnFor profitNDASep 4, 1964