phylloquinone
Small moleculeexperimental
Phytomenadione, also known as vitamin K1, phylloquinone, or phytonadione, is a vitamin found in food and used as a dietary supplement. It is on the World Health Organization's List of Essential Medicines. — Wikipedia
Clinical trial activity
11 trials · 17 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
4
Phase 3
4
Phase 4
2
Earliest trial started Sep 1, 2000 (NCT00062595)
Timeline
Indications
Approved for
Studied for
Mechanism of action
PROC agonist
Chemistry & pharmacology
Loading structure…
SMILES
CC1=C(C/C=C(\C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(=O)c2ccccc2C1=O- Mol. weight
- 450.71 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral, Parenteral
- Availability
- Prescription Only
Oral
Yes
Parenteral
Yes
Topical
No
Black box warning
Sources
- WikipediaPhytomenadione ↗
- ChEMBLCHEMBL1550 ↗
Also known as
- 2-methyl-3-phytyl-1,4-naphthochinon
- 2-methyl-3-phytyl-1,4-naphthochinon
- 2-methyl-3-phytyl-1,4-naphthoquinone
- 2-methyl-3-phytyl-1,4-naphthoquinone
- phyllochinonum
- phyllochinonum
- phylloquinone
- phylloquinone
- phylloquinone
- phylloquinone
- phylloquinone
- phylloquinone
- phythyl-menadion
- phythyl-menadion
- phytomenadione
- phytomenadione
- phytomenadione
- phytomenadione
- phytomenadione
- phytomenadionum
- phytonadionum
- phytonadionum
- trans-phylloquinone
- trans-phylloquinone
- vitamin k
- vitamin k
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06385275 | Phase 1/Phase 2 (Phase 2) | Dec 31, 2024 | Boston University, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
| NCT06839352 | Phase 4 | Oct 3, 2022 | Zagazig University |
| NCT05018221 | Phase 3 | Aug 26, 2021 | Australasian Kidney Trials Network, Salford Royal Foundation NHS Trust, University of Sydney, Waitemata District Health Board |
| NCT04752813 | Phase 2 | Aug 2, 2021 | Berg, LLC |
| NCT04477811 | Phase 2/Phase 3 (Phase 3) | Jul 25, 2020 | Ain Shams University |
| NCT05060809 | Phase 4 | Jan 1, 2018 | Assiut University |
| NCT03388970 | Early Phase 1 (Phase 1) | Aug 1, 2017 | China Medical University |
| NCT02278692 | N/A | Mar 1, 2015 | Harvard University, National Kidney Foundation |
| NCT01232647 | Phase 2/Phase 3 (Phase 3) | Apr 1, 2011 | University of London |
| NCT01910142 | N/A | Nov 1, 2008 | TNO |
| NCT00062595 | Phase 3 | Sep 1, 2000 | Eisai, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
Showing 11 of 11 trials
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Organizations
Research & Development (17)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ain Shams University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Assiut University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Australasian Kidney Trials Network | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Berg, LLC | For profit | 1 | 1 | 1 | 2021 |
| Boston University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| China Medical University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Eisai | For profit | 1 | 0 | 1 | 2000 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Government | 1 | 0 | 1 | 2024 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 1 | 1 | 1 | 2000 |
| National Kidney Foundation | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Salford Royal Foundation NHS Trust | Academic/Hospital | 1 | 0 | 1 | 2021 |
| TNO | For profit | 1 | 1 | 1 | 2008 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Sydney | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Waitemata District Health Board | Government | 1 | 0 | 1 | 2021 |
| Zagazig University | Academic/Hospital | 1 | 1 | 1 | 2022 |
17 organizations
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