meprobamate
Trade name: equanil
Approved
Apr 28, 1955
Meprobamate is a carbamate derivative used as an anxiolytic drug. Meprobamate enhances GABA-A currents, and at higher concentration, exhibits a separate channel-blocking effect that limits the magnitude of GABA(A) receptor potentiation. It is also a potent adenosine reuptake inhibitor (AdoRI), which is most likely responsible for its lesser degree of sedation compared to barbiturates. Meprobamate was withdrawn from European and Canadian markets due to its potential to cause physical and psychological dependence. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 46 marketing orgs
Timeline
1950s
- Apr 28, 1955
Earliest FDA Approval
- Apr 28, 1955
Medpointe — NDA Secondary Org
- Jul 26, 1955
Wyeth — First NDA Organization
- Jul 26, 1955
American Home Products — NDA Secondary Org
- Jul 26, 1955
Wyeth — NDA Organization
1960s
- May 27, 1960
Sun Pharmaceuticals — Marketing Organization
- May 27, 1960
Sun Pharmaceuticals — NDA Secondary Org
- Jul 3, 1963
Halsey — NDA Secondary Org
- Jul 26, 1963
Sandoz — NDA Secondary Org
- Aug 9, 1963
Lannett Company, Inc. — NDA Secondary Org
- Aug 9, 1963
Chartwell Pharmaceuticals — Marketing Organization
- Aug 9, 1963
Chartwell Pharmaceuticals — NDA Secondary Org
- Apr 13, 1964
Mallard — NDA Secondary Org
- Dec 12, 1964
West-Ward Pharmaceutical — NDA Secondary Org
- Jan 27, 1967
Solvay — NDA Secondary Org
1970s
- Jul 29, 1971
Alta Pharma — Marketing Organization
- Jul 12, 1972
Aurobindo Pharma — Marketing Organization
- Jul 12, 1972
Rising Pharmaceuticals — Marketing Organization
- Apr 23, 1973
Watson Pharmaceuticals — Marketing Organization
- Dec 20, 1973
Whiteworth Towne Paulsen — Marketing Organization
- Jan 28, 1974
Medpointe — Marketing Organization
- Apr 29, 1974
Teva — Marketing Organization
- May 10, 1974
Ferndale Laboratories, Inc. — Marketing Organization
- Jul 3, 1974
IVC — Marketing Organization
- Jul 3, 1974
Acella Pharmaceuticals — Marketing Organization
- Jul 10, 1974
Barr Laboratories — Marketing Organization
- Sep 30, 1974
Nexgen Pharma, Inc — Marketing Organization
- Feb 21, 1975
Mylan — NDA Secondary Org
- Dec 9, 1975
Parke-Davis — Marketing Organization
- Dec 9, 1975
Warner Lambert — Marketing Organization
- Jan 26, 1977
Stanford Laboratories — NDA Secondary Org
1980s
- Mar 18, 1982
Upsher-Smith Laboratories — Marketing Organization
- Jul 14, 1982
Vanguard — Marketing Organization
- Jan 25, 1983
Perrigo — Marketing Organization
- Nov 25, 1987
Lee Km — Marketing Organization
1990s
- Sep 16, 1994
Sandoz — Marketing Organization
2000s
- Feb 27, 2008
Invagen Pharms — Marketing Organization
- Feb 18, 2009
Alembic — Marketing Organization
2010s
- May 23, 2011
Taro Pharmaceuticals — Marketing Organization
Indications
Approved for
Mechanism of action
- GABA-A receptorBINDING AGENT
GABA-A receptor binding agent
Combination products
equagesic
with acetylsalicylic acid
Also known as mepro-aspirin, micrainin
pmb
Approval history
- approvedApr 28, 1955
Chemistry & pharmacology
SMILES
CCCC(C)(COC(N)=O)COC(N)=O- Mol. weight
- 218.2502 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Prescription Only
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaMeprobamate ↗
- NCATS9I7LNY769Q ↗
- ChEMBLCHEMBL979 ↗
Also known as
- equanil
- equanil
- mepriam
- mepriam
- meprobam
- meprobamat
- meprobamat
- meprobamat
- meprobamate
- meprobamate
- meprobamate
- meprobamate
- meprobamate
- meprobamate
- meprobamate
- meprobamate
- meprobamate
- meprobamate
- meprobamate
- meprobamato
- meprobamato
- meprobamatum
- meprobamatum
- meprobamic acid
- meprobamic acid
- meproban
- meprocompren
- meprospan
- meprospan
- miltown
- miltown
- miltown
- miltown
- neuramate
- neuramate
- tenavoid
- tranmep
- tranmep
Organizations
Marketing (54)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Acella Pharmaceuticals | For profit | MKTG | Jul 3, 1974 |
| Alembic | For profit | MKTG | Feb 18, 2009 |
| Alta Pharma | For profit | MKTG | Jul 29, 1971 |
| American Home Products | For profit | NDA2 | Jul 26, 1955 |
| Aurobindo Pharma | For profit | MKTG | Jul 12, 1972 |
| Barr Laboratories | For profit | MKTG | Jul 10, 1974 |
| Bausch Health Companies | For profit | NDA2 | — |
| Chartwell Pharmaceuticals | For profit | MKTG | Aug 9, 1963 |
| Chartwell Pharmaceuticals | For profit | NDA2 | Aug 9, 1963 |
| Elkins Sinn | For profit | NDA2 | — |
| Ferndale Laboratories, Inc. | For profit | MKTG | May 10, 1974 |
| Halsey | For profit | NDA2 | Jul 3, 1963 |
| Heather Pharma | For profit | NDA2 | — |
| Heather Pharma | For profit | MKTG | — |
| IVC | For profit | MKTG | Jul 3, 1974 |
| Impax Laboratories | For profit | NDA2 | — |
| Invagen Pharms | For profit | MKTG | Feb 27, 2008 |
| Lannett Company, Inc. | For profit | NDA2 | Aug 9, 1963 |
| Lederle | For profit | MKTG | — |
| Lee Km | For profit | MKTG | Nov 25, 1987 |
| MK Labs | For profit | NDA2 | — |
| Mallard | For profit | NDA2 | Apr 13, 1964 |
| Medpointe | For profit | NDA2 | Apr 28, 1955 |
| Medpointe | For profit | MKTG | Jan 28, 1974 |
| Mylan | For profit | NDA2 | Feb 21, 1975 |
| Mylan | For profit | MKTG | — |
| Nexgen Pharma, Inc | For profit | MKTG | Sep 30, 1974 |
| Par Pharmaceuticals | For profit | MKTG | — |
| Parke-Davis | For profit | MKTG | Dec 9, 1975 |
| Perrigo | For profit | MKTG | Jan 25, 1983 |
| Pharmavite | For profit | MKTG | — |
| Puracap Pharmaceutical | For profit | MKTG | — |
| Quantum Pharmaceutical | For profit | MKTG | — |
| R.P. Scherer | For profit | MKTG | — |
| Rising Pharmaceuticals | For profit | MKTG | Jul 12, 1972 |
| Roxane Laboratories | For profit | MKTG | — |
| Sandoz | For profit | NDA2 | Jul 26, 1963 |
| Sandoz | For profit | MKTG | Sep 16, 1994 |
| Solvay | For profit | NDA2 | Jan 27, 1967 |
| Solvay | For profit | MKTG | — |
| Stanford Laboratories | For profit | NDA2 | Jan 26, 1977 |
| Sun Pharmaceuticals | For profit | MKTG | May 27, 1960 |
| Sun Pharmaceuticals | For profit | NDA2 | May 27, 1960 |
| Tablicaps | For profit | MKTG | — |
| Taro Pharmaceuticals | For profit | MKTG | May 23, 2011 |
| Teva | For profit | MKTG | Apr 29, 1974 |
| Teva | For profit | NDA2 | — |
| Upsher-Smith Laboratories | For profit | MKTG | Mar 18, 1982 |
| Vanguard | For profit | MKTG | Jul 14, 1982 |
| Warner Lambert | For profit | MKTG | Dec 9, 1975 |
| Watson Pharmaceuticals | For profit | MKTG | Apr 23, 1973 |
| West-Ward Pharmaceutical | For profit | NDA2 | Dec 12, 1964 |
| Whiteworth Towne Paulsen | For profit | MKTG | Dec 20, 1973 |
| Wyeth | For profit | NDA | Jul 26, 1955 |