sulfur

Small moleculeapproved

Approved

Sep 17, 1940

Mercury(I) iodide is a chemical compound that has been used as a drug in the 19th century, sometimes under the contemporary name of 'protiodide of mercury'. Mercury(I) iodide was used to treat a wide range of conditions; everything from acne to kidney disease and in particular was the treatment of choice for syphilis. It was available over the counter at any drugstore in the world, the most common form being a concoction of protiodide, licorice, glycerin, and marshmallow. Taken orally, and in low doses, protiodide causes excessive salivation, fetid breath, spongy and bleeding gums, and sore teeth. Excessive use or an overdose causes physical weakness, loss of teeth, hemolysing (destruction of the red blood cells) of the blood and necrosis of the bones and tissues of the body. Early signs of an overdose or excessive use are muscular tremors, chorea, and locomotor ataxia. Violent bloody vomiting and voiding also occur. — NCATS

Clinical trial activity

4 trials · 6 clinical orgs · 1 marketing orgs

Phase 1
0
Phase 2
2
Phase 3
2
Phase 4
2

Earliest trial started Apr 1, 2009 (NCT00877409)

Timeline

1940s

  1. Sep 17, 1940

    AH Robins — Earliest FDA Approval

  2. Sep 17, 1940

    Evidence of US Marketing

  3. Sep 17, 1940

    AH Robins — Marketing Organization

  4. Sep 17, 1940

    AH Robins — NDA Secondary Org

  5. Sep 17, 1940

    AH Robins — NDA Organization

2000s

  1. Jan 1, 2009

    Earliest Phase 3 Sponsor(trial)

Indications

Mechanism of action

  • Unspecified targetUnclear

    Unclear

Approval history

  • approvedSep 17, 1940
  • approvedSep 17, 1940

Chemistry & pharmacology

Loading structure…

SMILES

S1SSSSSSS1
Mol. weight
256.52 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Topical
Availability
Discontinued

Oral

No

Parenteral

No

Topical

Yes

Sources

Also known as

  • acnaveen
  • acnil
  • bensulfoid
  • bensulfoid
  • cuticura
  • dome-acne
  • eskamel
  • liquamat
  • liquamat
  • meted
  • sastid
  • sastid
  • sulfur
  • sulfur
  • sulfur
  • sulfur
  • sulfur
  • sulfur
  • sulfur
  • sulfur
  • sulfur
  • sulfur compounds
  • sulfur compounds
  • sulfur precipitated
  • sulfur precipitated
  • sulfur, precipitated
  • sulfur, precipitated
  • sulfur soap
  • sulfur soap
  • sulfur, sublimed
  • sulfur, sublimed
  • sulphur
  • sulphur

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06170333Phase 4Aug 25, 2023Padjadjaran University
NCT06396507Phase 3Mar 15, 2022Damascus University, Tishreen University, University of Aleppo
NCT01260571Phase 4Jan 1, 2011Zurita Laboratorio Farmaceutico Ltda.
NCT00877409Phase 3Apr 1, 2009Medcin Instituto da Pele, Zurita Laboratorio Farmaceutico Ltda.
Showing 4 of 4 trials
Page 1 / 1

Organizations

Research & Development (6)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Zurita Laboratorio Farmaceutico Ltda.For profit2222009
Damascus UniversityAcademic/Hospital1112022
Medcin Instituto da PeleAcademic/Hospital1012009
Padjadjaran UniversityAcademic/Hospital1112023
Tishreen UniversityAcademic/Hospital1012022
University of AleppoAcademic/Hospital1012022
6 organizations
Page 1 / 1

Marketing (3)

OrganizationOrg typeRelationshipDate
AH RobinsFor profitMKTGSep 17, 1940
AH RobinsFor profitNDA2Sep 17, 1940
AH RobinsFor profitNDASep 17, 1940