triflupromazine
Trade name: vesprin
Small moleculeapproved
Approved
Sep 16, 1957
Triflupromazine is antipsychotic and an antiemetic drug (sold under the brand names VESPRIN) which used to management of psychoses. However, this drug was discontinued. Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. Moreover, binds the muscarinic acetylcholine receptors (M1 and M2). — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 3 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1950s
- Sep 16, 1957
Smith, Kline & French — Earliest FDA Approval
- Sep 16, 1957
Bristol-Myers Squibb — NDA Secondary Org
- Sep 16, 1957
Smith, Kline & French — NDA Organization
- Jan 6, 1958
Apothecon — NDA Secondary Org
Indications
Approved for
Mechanism of action
- Dopamine D2 receptorANTAGONIST
DRD2 antagonist
Approval history
- approvedSep 16, 1957
Chemistry & pharmacology
Loading structure…
SMILES
CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21- Mol. weight
- 352.43 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral, Parenteral
- Availability
- Discontinued
Oral
Yes
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL570 ↗
- WikipediaTriflupromazine ↗
- NCATSRO16TQF95Y ↗
- ChEMBLCHEMBL1201102 ↗
Also known as
- 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine
- 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine
- 2-trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine
- 2-trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine
- 2-(trifluoromethyl)promazine
- 2-(trifluoromethyl)promazine
- fluopromazine
- fluopromazine
- fluopromazine
- fluopromazine
- nivoman
- nivoman
- psyquil
- trifluopromazine
- triflupromazin
- triflupromazin
- triflupromazina
- triflupromazina
- triflupromazine
- triflupromazine
- triflupromazine
- triflupromazine
- triflupromazine
- triflupromazine
- triflupromazine
- triflupromazine
- triflupromazine
- triflupromazine
- triflupromazine
- triflupromazine hcl
- triflupromazine hcl
- triflupromazine hcl
- triflupromazine hydrochloride
- triflupromazine hydrochloride
- triflupromazine hydrochloride
- triflupromazine hydrochloride
- triflupromazinum
- triflupromazinum
- vesprin
- vesprin
- vesprin
- vetame
- vetame
Organizations
Marketing (3)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Apothecon | For profit | NDA2 | Jan 6, 1958 |
| Bristol-Myers Squibb | For profit | NDA2 | Sep 16, 1957 |
| Smith, Kline & French | For profit | NDA | Sep 16, 1957 |