lindane

Trade name: kwell

Small moleculeapproved

Approved

Jun 1, 1951

Lindane is an isomer of hexachlorocyclohexane that has been used both as an agricultural insecticide and as a pharmaceutical. As a shampoo, lindane is used for treamtment lice infestation. Lindane lotion is used for treatment of scabies. Due to toxicities, associated with lindane, it is used only in patients who cannot tolerate or have failed first-line treatment with safer medication. Lindane exerts its parasiticidal action by being directly absorbed into the parasites and their ova, where it interferes with GABA neurotransmitter function by interacting with the GABAA channel complex at the picrotoxin binding site. — NCATS

Clinical trial activity

2 trials · 2 clinical orgs · 6 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started May 1, 2009 (NCT02213055)

Timeline

1940s

Jun 1, 1948
Block Drug — First NDA Organization
Jun 1, 1948
Block Drug — NDA Organization

1950s

Jun 1, 1951
Earliest FDA Approval

1970s

Dec 19, 1974
Carnrick Laboratories — Marketing Organization
Jun 15, 1976
Johnson and Johnson — Marketing Organization

1980s

Dec 17, 1981
Olta Pharms — Marketing Organization
Sep 18, 1984
Wockhardt — Marketing Organization

2000s

Jan 1, 2009
Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

GABA-A receptorNEGATIVE ALLOSTERIC MODULATOR
GABA-A receptor negative allosteric modulator
mode not clear, but seems negative and likely allosteric, binds at picrotoxin site?
GABA-A receptorNEGATIVE ALLOSTERIC MODULATOR
GABA-A receptor negative allosteric modulator
mode not clear, but seems negative and likely allosteric, binds at picrotoxin site?

Approval history

approvedJun 1, 1951

Chemistry & pharmacology

Loading structure…

SMILES

Cl[C@H]1[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@@H]1Cl

Mol. weight: 290.83 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Racemic Mixture
Inorganic: No
Polymer: No
Delivery: Topical
Availability: Prescription Only

Oral

Parenteral

Topical

Yes

Sources

Also known as

1,2,3,4,5,6-hexachlorocyclohexane
1,2,3,4,5,6-hexachlorocyclohexane
(1alpha,2alpha,3beta,4alpha,5alpha,6beta)-1,2,3,4,5,6-hexachlorocyclohexane
(1alpha,2alpha,3beta,4alpha,5alpha,6beta)-1,2,3,4,5,6-hexachlorocyclohexane
(1r,2c,3t,4c,5c,6t)-1,2,3,4,5,6-hexachlorocyclohexane
(1r,2c,3t,4c,5c,6t)-1,2,3,4,5,6-hexachlorocyclohexane
benzene hexachloride
benzene hexachloride
benzene hexachloride, gamma
benzene hexachloride, gamma
esoderm
esoderm
gamene
gamene
gamma-1,2,3,4,5,6-hexachlorocyclohexane
gamma-1,2,3,4,5,6-hexachlorocyclohexane
gamma benzene hcl
gamma benzene hexachloride
gamma benzene hexachloride
gamma-benzene hexachloride
gamma-benzene hexachloride
gamma-bhc
gamma-bhc
gamma-hch
gamma-hch
gamma-hexachlorocyclohexane
gamma-hexachlorocyclohexane
gamma-hexachlorocyclohexane
gamma-hexachlorzyklohexan
gamma-hexachlorzyklohexan
gamma-lindane
gamma-lindane
gammallin
gammallin
gammallin
gammaxene
gammaxene
gammaxene
gammexane
gammexane
gexane
gexane
hexachloran
hexachlorane
hexachlorane
hexachlorane
hexachlorocyclohexane
hexicide
hexicide
kwell
kwell
kwell
kwells
kwells
kwells kids
lindan
lindan
lindane
lindane
lindane
lindane
lindane
lindane
lindane
lindane
lindane
lindane
lindane
lindane
lorexane
lorexane
lorexane no 3
quellada
quellada
quellada-m
scabene
scabene
γ-hexachlorocyclohexane
γ-hexachlorocyclohexane
γ-hexachlorzyklohexan
γ-hexachlorzyklohexan
γ-lindane
γ-lindane

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT03270839	Phase 4	Jun 1, 2017	Israel Defense Force
NCT02213055	Phase 2	May 1, 2009	Rutgers University

Showing 2 of 2 trials

Page 1 / 1

Organizations

Research & Development (2)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Israel Defense Force	Government	1	1	1	2017
Rutgers University	Academic/Hospital	1	1	1	2009

2 organizations

Page 1 / 1

Marketing (8)

Organization	Org type	Relationship	Date
Block Drug	For profit	NDA	Jun 1, 1948
Carnrick Laboratories	For profit	MKTG	Dec 19, 1974
Carnrick Laboratories	For profit	NDA2	—
Johnson and Johnson	For profit	MKTG	Jun 15, 1976
Olta Pharms	For profit	MKTG	Dec 17, 1981
Stiefel Laboratories	For profit	MKTG	—
Wockhardt	For profit	SYN	Aug 16, 1984
Wockhardt	For profit	MKTG	Sep 18, 1984