thiothixene
Trade name: navane
Approved
Jul 24, 1967
THIOTHIXENE, (E)- (trans-thiothixene) )is a clinically inactive isomer of thiothixene. 1000 times higher concentration of this isomer than the active cis-isomer required to inhibit release of (3H) dopamine from rat striatal slices. Trans-thiothixene is about 50 times less potent than cis-thiothixene in inhibiting 3H-haloperidol binding at their binding sites in the rat brain. Cis-isomer of thiothixene is the active antipsychotic drug used in antipsychotic therapy. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 15 marketing orgs
Timeline
1980s
- Jun 5, 1987
Watson Pharmaceuticals — Marketing Organization
- Jun 5, 1987
Heritage Pharma — Marketing Organization
- Jun 5, 1987
Chartwell Pharmaceuticals — Marketing Organization
- Jun 22, 1987
Teva — Marketing Organization
- Jun 23, 1987
Mylan — Marketing Organization
- Jun 23, 1987
Rising Pharmaceuticals — Marketing Organization
- Jun 24, 1987
Epic Pharma Llc — Marketing Organization
- Jun 24, 1987
Sandoz — Marketing Organization
2010s
- Apr 5, 2019
Novitium Pharma — Marketing Organization
2020s
- Feb 28, 2022
Amneal Pharmaceuticals — Marketing Organization
Indications
Approved for
Mechanism of action
- Serotonin 2a (5-HT2a) receptorANTAGONIST
HTR2A antagonist
- Dopamine D2 receptorANTAGONIST
DRD2 antagonist
Approval history
- approvedJul 24, 1967
Chemistry & pharmacology
SMILES
CN1CCN(CC/C=C2/c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1.Cl.Cl.O.O- Mol. weight
- 552.59 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral, Parenteral
- Availability
- Discontinued
Oral
Yes
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL3989824 ↗
- WikipediaTiotixene ↗
- NCATS7318FJ13YJ ↗
- ChEMBLCHEMBL1201 ↗
- ChEMBLCHEMBL1200902 ↗
Also known as
- cis-thiothixene
- cis-thiothixene
- cis-thiothixene
- cp-122521
- cp-122521
- cp-12252-1
- cp-12252-1
- (e)-thiothixene
- (e)-thiothixene
- navane
- navane
- navane
- orbinamon
- orbinamon
- p-4657b
- p-4657b
- thiothixene
- thiothixene
- thiothixene
- thiothixene
- thiothixene
- thiothixene
- thiothixene
- thiothixene
- thiothixene
- thiothixene
- thiothixene
- thiothixene hcl
- thiothixene hcl
- thiothixene hcl
- thiothixene hydrochloride
- thiothixene hydrochloride
- thiothixene hydrochloride
- thiothixene hydrochloride
- thiothixene hydrochloride intensol
- thiothixene hydrochloride intensol
- thiothixine
- thiothixine
- tiotixene
- tiotixene
- tiotixene
- tiotixene
- tiotixeno
- tiotixeno
- tiotixenum
- tiotixenum
Organizations
Marketing (18)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Alpharma | For profit | MKTG | — |
| Am Therap | For profit | MKTG | — |
| Amneal Pharmaceuticals | For profit | MKTG | Feb 28, 2022 |
| Chartwell Pharmaceuticals | For profit | MKTG | Jun 5, 1987 |
| Epic Pharma Llc | For profit | MKTG | Jun 24, 1987 |
| Epic Pharma Llc | For profit | SYN | Jun 24, 1987 |
| Heritage Pharma | For profit | SYN | Jun 5, 1987 |
| Heritage Pharma | For profit | MKTG | Jun 5, 1987 |
| Hikma | For profit | MKTG | — |
| Mylan | For profit | MKTG | Jun 23, 1987 |
| Novitium Pharma | For profit | MKTG | Apr 5, 2019 |
| Paco | For profit | MKTG | — |
| Pfizer | For profit | NDA | Jul 24, 1967 |
| Rising Pharmaceuticals | For profit | MKTG | Jun 23, 1987 |
| Sandoz | For profit | MKTG | Jun 24, 1987 |
| Teva | For profit | MKTG | Jun 22, 1987 |
| Teva | For profit | SYN | Oct 16, 1987 |
| Watson Pharmaceuticals | For profit | MKTG | Jun 5, 1987 |