methdilazine
Trade name: tacaryl
Small moleculeapproved
Approved
Jun 1, 1960
Methdilazine is a phenothiazine compound with antihistaminic activity. Methdilazine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. It is used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
Indications
Approved for
Mechanism of action
- Histamine H1 receptorANTAGONIST
HRH1 antagonist
Approval history
- approvedJun 1, 1960
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCC(CN2c3ccccc3Sc3ccccc32)C1- Mol. weight
- 296.44 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1200959 ↗
- WikipediaMethdilazine ↗
- NCATS4Q13LY9Z8X ↗
- ChEMBLCHEMBL1200532 ↗
Also known as
- methdilazine
- methdilazine
- methdilazine
- methdilazine
- methdilazine
- methdilazine
- methdilazine
- methdilazine
- methdilazine
- methdilazine
- methdilazine
- methdilazine hcl
- methdilazine hcl
- methdilazine hcl
- methdilazine hydrochloride
- methdilazine hydrochloride
- methdilazine hydrochloride
- methdilazine hydrochloride
- methdilazine hydrochloride
- methdilazinum
- methdilazinum
- metodilazina
- metodilazina
- tacaryl
- tacaryl
- tacaryl