thyroglobulin
Trade name: proloid
Desiccated thyroid extract (DTE), is thyroid gland that has been dried and powdered for medical use. It is used to treat hypothyroidism, but less preferred than levothyroxine. It is taken by mouth. Maximal effects may take up to three weeks to occur. — Wikipedia
Clinical trial activity
2 trials · 1 clinical orgs · 3 marketing orgs
Earliest trial started May 1, 2012 (NCT01739972)
Timeline
1950s
- Jun 1, 1953
Warner Chilcott — First NDA Organization
- Jun 1, 1953
Warner Chilcott — NDA Organization
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Iodine storage agent
It is a synthetic thyroglobulin, hence it works as an iodine storage, and when necessary it is degraded in lysossomes into T4 and T3 hormones
- Thyroid hormone receptorSUBSTRATE
Thyroid hormone receptor substrate
It is a synthetic thyroglobulin, hence it works as an iodine storage, and when necessary it is degraded in lysossomes into T4 and T3 hormones
Approval history
- approved—
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaDesiccated thyroid extract ↗
- NCATS6RV024OAUQ ↗
- ChEMBLCHEMBL2108878 ↗
- ChEMBLCHEMBL1201650 ↗
- WikipediaThyroglobulin ↗
- NCATSNN2P9VPL7M ↗
Also known as
- desiccated thyroid extract
- dried thyroid
- nature
- nature
- proloid
- thyroglobulin
- thyroglobulin
- thyroglobulin
- thyroglobuline
- thyroglobulinum
- thyroid
- thyroid
- thyroid gland preparations
- thyroid tablets
- tiroglobulina
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02317926 | N/A | May 1, 2015 | United States Army |
| NCT01739972 | N/A | May 1, 2012 | United States Army |
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| United States Army | Government | 2 | 2 | 1 | 2012 |
Marketing (3)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Impax Laboratories | For profit | MKTG | — |
| Parke-Davis | For profit | NDA2 | — |
| Warner Chilcott | For profit | NDA | Jun 1, 1953 |