thenalidine
Small moleculeexperimental
Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets due to a risk of neutropenia. Thenalidine is an antagonist of the H1-receptor. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Indications
Approved for
Mechanism of action
- Histamine H1 receptorANTAGONIST
HRH1 antagonist
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCC(CC1)N(CC2=CC=CS2)C3=CC=CC=C3- Mol. weight
- 286.435 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaThenalidine ↗
- NCATS6U94N2D00F ↗
- ChEMBLCHEMBL2105458 ↗
Also known as
- 1-methyl-4-amino-n-phenyl-n-(2-thenyl)piperidine
- 1-methyl-4-amino-n-phenyl-n-(2-thenyl)piperidine
- 1-methyl-4-(n-2-thenylanilino)piperidine
- 1-methyl-4-n-2-thenylanilinopiperidine
- 1-methyl-4-n-2-thenylanilinopiperidine
- tenalidina
- tenalidina
- thenaldine
- thenaldine
- thenaldine
- thenaldine
- thenalidin
- thenalidine
- thenalidine
- thenalidine
- thenalidine
- thenalidine
- thenalidine
- thenalidine
- thenalidine
- thenalidinum
- thenalidinum
- thenophenopiperidine
- thenophenopiperidine
- thenophenopiperidine