tedisamil sesquifumarate
Small moleculeexperimental
Clinical trial activity
3 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
3
Phase 4
0
Earliest trial started Oct 1, 2004 (NCT00126061)
Timeline
2000s
- Jan 1, 2004
Earliest Phase 3 Sponsor(trial)
Indications
Mechanism of action
Voltage-gated potassium channel blocker
Potassium channel blocker that inhibits both transient outward (Ito) and delayed rectifier (IK) potassium currents.
- Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) ↗
- Potassium voltage-gated channel subfamily D member 3 (KCND3) ↗
- Potassium voltage-gated channel subfamily H member 2 (KCNH2) ↗
- Potassium voltage-gated channel subfamily A member 2 (KCNA2) ↗
- Potassium voltage-gated channel subfamily A member 1 (KCNA1) ↗
- Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2) ↗
- Potassium voltage-gated channel subfamily KQT member 3 (KCNQ3) ↗
- Potassium voltage-gated channel subfamily A member 7 (KCNA7) ↗
- Potassium voltage-gated channel subfamily KQT member 5 (KCNQ5) ↗
- Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4) ↗
- Potassium voltage-gated channel subfamily H member 1 (KCNH1) ↗
- Potassium voltage-gated channel subfamily A member 4 (KCNA4) ↗
- Potassium voltage-gated channel subfamily A member 5 (KCNA5) ↗
- Potassium voltage-gated channel subfamily A member 3 (KCNA3) ↗
- Potassium voltage-gated channel subfamily A member 6 (KCNA6) ↗
- Potassium voltage-gated channel subfamily C member 1 (KCNC1) ↗
- Potassium voltage-gated channel subfamily D member 2 (KCND2) ↗
- Potassium voltage-gated channel subfamily B member 2 (KCNB2) ↗
- Potassium voltage-gated channel subfamily C member 4 (KCNC4) ↗
- Potassium voltage-gated channel subfamily C member 3 (KCNC3) ↗
- Potassium voltage-gated channel subfamily B member 1 (KCNB1) ↗
- Potassium voltage-gated channel subfamily A member 10 (KCNA10) ↗
- Potassium voltage-gated channel subfamily V member 1 (KCNV1) ↗
- Potassium voltage-gated channel subfamily H member 5 (KCNH5) ↗
- Potassium voltage-gated channel subfamily G member 3 (KCNG3) ↗
- Potassium voltage-gated channel subfamily G member 4 (KCNG4) ↗
- Potassium voltage-gated channel subfamily V member 2 (KCNV2) ↗
- Potassium voltage-gated channel subfamily S member 1 (KCNS1) ↗
- Potassium voltage-gated channel subfamily H member 8 (KCNH8) ↗
- Potassium voltage-gated channel subfamily C member 2 (KCNC2) ↗
- Potassium voltage-gated channel subfamily S member 3 (KCNS3) ↗
- Potassium voltage-gated channel subfamily H member 6 (KCNH6) ↗
- Potassium voltage-gated channel subfamily F member 1 (KCNF1) ↗
- Potassium voltage-gated channel subfamily H member 7 (KCNH7) ↗
- Potassium voltage-gated channel subfamily D member 1 (KCND1) ↗
- Potassium voltage-gated channel subfamily G member 1 (KCNG1) ↗
- Potassium voltage-gated channel subfamily G member 2 (KCNG2) ↗
- Potassium voltage-gated channel subfamily H member 3 (KCNH3) ↗
- Potassium voltage-gated channel subfamily S member 2 (KCNS2) ↗
- Potassium voltage-gated channel subfamily H member 4 (KCNH4) ↗
- HERG
- Voltage-gated potassium channel subunit Kv1.5
- Voltage-gated potassium channel subunit Kv7.2
- Voltage-gated potassium channel subunit Kv1.2
- Voltage-gated potassium channel subunit Kv1.3
- Voltage-gated potassium channel subunit Kv7.4
- Voltage-gated potassium channel subunit Kv4.3
- Voltage-gated potassium channel subunit Kv1.7
- Voltage-gated potassium channel subunit Kv7.5
- Voltage-gated potassium channel subunit Kv1.1
- Voltage-gated potassium channel subunit Kv7.1
- Voltage-gated potassium channel subunit Kv7.3
- Voltage-gated potassium channel subunit Kv1.6
- Voltage-gated potassium channel subunit Kv3.1
- Voltage-gated potassium channel subunit Kv1.4
- Potassium voltage-gated channel subfamily D member 2
- Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3)
- Potassium voltage-gated channel subfamily B member 2
- Potassium voltage-gated channel subfamily B member 1
- Potassium voltage-gated channel subfamily C member 2
- Potassium voltage-gated channel subfamily H member 3
- KCNQ (Kv7) potassium channel
- Voltage-gated potassium channel KCNQ3/KCNQ4
- Voltage-gated potassium channel KCNQ3/KCNQ5
- KCNQ4/KCNQ5
- Voltage-gated potassium channel subunit Kv10.1
- Potassium voltage-gated channel subfamily A member 10
- Potassium voltage-gated channel subfamily H member 6
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Loading structure…
SMILES
C1CCC2(C1)[C@H]1CN(CC3CC3)C[C@@H]2CN(CC2CC2)C1.C1CCC2(C1)[C@H]1CN(CC3CC3)C[C@@H]2CN(CC2CC2)C1.O=C(O)/C=C/C(=O)O.O=C(O)/C=C/C(=O)O.O=C(O)/C=C/C(=O)O- Mol. weight
- 925.17 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2107378 ↗
- ChEMBLCHEMBL2146111 ↗
- ChEMBLCHEMBL2111110 ↗
- ChEMBLCHEMBL113461 ↗
Also known as
- 3,7-di-(cyclopropylmethyl)-9,9-tetramethylene-3,7-diazabicyclo(3.3.1)nonane
- kc 8857
- kc-8857
- kc-8857
- kc-8857
- kc-8857
- kc-8857
- tedisamil
- tedisamil
- tedisamil
- tedisamil
- tedisamil
- tedisamil sesquifumarate
- tedisamil sesquifumarate
- tedisamil sesquifumarate
- tedisamil sesquifumarate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00126022 | Phase 3 | Dec 1, 2004 | Solvay |
| NCT00126061 | Phase 3 | Oct 1, 2004 | Solvay |
| NCT00126074 | Phase 3 | Oct 1, 2004 | Solvay |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Solvay | For profit | 3 | 3 | 1 | 2004 |
1 organizations
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