pirprofen
Small moleculeexperimental
Pirprofen was a nonsteroidal anti-inflammatory drug (NSAID) that was brought to market by Ciba-Geigy in 1982 as a treatment for arthritis and pain. Its label was restricted after adverse events arose, including some cases of fatal liver toxicity. Ciba-Geigy voluntarily withdrew the drug from the market worldwide in 1990. — Wikipedia
Clinical trial activity
0 trials · 0 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Mechanism of action
- CyclooxygenaseINHIBITOR
Cyclooxygenase inhibitor
Inhibits the conversion of arachidonic acid into prostaglandin E2 by prostaglandin synthase in a competitive and reversible way.
Chemistry & pharmacology
Loading structure…
SMILES
CC(C(=O)O)c1ccc(N2CC=CC2)c(Cl)c1- Mol. weight
- 251.71 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPirprofen ↗
- ChEMBLCHEMBL188952 ↗
Also known as
- 2-(3-chloro-4-(3-pyrroli-1-yl)phenyl)propionic acid
- pirprofen
- pirprofen
- pirprofen
- pirprofen
- pirprofen
- pirprofen
- pirprofen
- racemic pirprofen
- rengasil
- rengasil
- su-21524
- su-21524
- su-21524