norethynodrel
Small moleculeapproved
Approved
Mar 9, 1961
Norethynodrel is a steroidal progestin of the 19-nortestosterone group and an isomer of norethisterone. Norethynodrel is a progesteron agonist with very weak estrogenic activiry. Noretynodrel was introduced in 1957 in Enovid, a combination formulation of noretynodrel and mestranol, for the treatment of gynecological and menstrual disorders.A few years later, in May 1960, Enovid was also approved as the first oral contraceptive. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1960s
- Mar 9, 1961
G D Searle — Earliest FDA Approval
- Mar 9, 1961
G D Searle — NDA Secondary Org
- Mar 9, 1961
G D Searle — NDA Organization
Indications
Mechanism of action
- Progesterone receptorAGONIST
PGR agonist
Combination products
enovi
with mestranol
Also known as enovid-e
Approval history
- approvedMar 9, 1961
Chemistry & pharmacology
Loading structure…
SMILES
C[C@]12CC[C@H]3[C@@H](CCC4=C3CCC(=O)C4)[C@@H]1CC[C@@]2(O)C#C- Mol. weight
- 298.4192 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaNoretynodrel ↗
- NCATS88181ACA0M ↗
- ChEMBLCHEMBL1387 ↗
Also known as
- norethinodrel
- norethynodrel
- norethynodrel
- norethynodrel
- norethynodrel
- norethynodrel
- norethynodrel
- norethynodrel
- noretynodrel
- noretynodrel
- noretynodrel
Organizations
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| G D Searle | For profit | NDA2 | Mar 9, 1961 |
| G D Searle | For profit | NDA | Mar 9, 1961 |