cyt997
Small moleculeexperimental
Clinical trial activity
2 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Jan 1, 2008 (NCT00664378)
Timeline
Indications
Mechanism of action
- TubulinINHIBITOR
Tubulin inhibitor
Microtubule polymerization inhibitor
Lexibulin forms H-bonds with the main chain of betaV236 on H7, betaD249 on T7 and aT179 on T5
- Tubulin beta-4B chain (TUBB4B) ↗
- Tubulin beta-1 chain (TUBB1) ↗
- Tubulin alpha-3C chain (TUBA3C) ↗
- Tubulin alpha-4A chain (TUBA4A) ↗
- Tubulin beta-3 chain (TUBB3) ↗
- Tubulin alpha-1A chain (TUBA1A) ↗
- Tubulin beta-4A chain (TUBB4A) ↗
- Tubulin beta-8 chain (TUBB8) ↗
- Tubulin beta chain (TUBB) ↗
- Tubulin alpha-1B chain (TUBA1B) ↗
- Tubulin alpha-1C chain (TUBA1C) ↗
- Tubulin alpha-3E chain (TUBA3E) ↗
- Tubulin beta-2A chain (TUBB2A) ↗
- Tubulin beta-2B chain (TUBB2B) ↗
- Tubulin beta-6 chain (TUBB6) ↗
Chemistry & pharmacology
Loading structure…
SMILES
CCC[C@H](Nc1nc(-c2ccc(NC(=O)NCC)c(OC)c2)ncc1C)c1cccnc1- Mol. weight
- 434.54 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL552212 ↗
Also known as
- cyt997
- cyt997
- cyt997
- cyt-997
- cyt-997
- lexibulin
- lexibulin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00650949 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2009 | Flinders University, Gilead Sciences, Peninsula Health, University of Sydney |
| NCT00664378 | Phase 2 | Jan 1, 2008 | Gilead Sciences, Monash University |
Showing 2 of 2 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Gilead Sciences | For profit | 2 | 2 | 1 | 2008 |
| Flinders University | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Monash University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Peninsula Health | Academic/Hospital | 1 | 0 | 1 | 2009 |
| University of Sydney | Academic/Hospital | 1 | 0 | 1 | 2009 |
5 organizations
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