isoetharine
Trade name: bronkosol
Approved
Jun 1, 1961
Isoetharine is a beta-2 adrenergic receptor agonist, which was developed by Max Bockmuhl, Gustav Erhart and Leonhard Stein at the Hochst laboratories of I.G. Farbenindustrie in 1934. By binding to beta-2 adrenergic receptors on bronchial cell membranes, isoetharine increases the level of cAMP and thus stimulates the relaxation of smooth-muscle cells, stabilizes mast cells and inhibits histamine release. Isoetharine was approved by FDA for the symptomatic relief of bronchiospasms in patients with chronic bronchitis or emphysema (aerosol and solution for inhalation), however, later on the drug was discontinued. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 13 marketing orgs
Timeline
1960s
- Jun 1, 1961
Earliest FDA Approval
- Jun 1, 1966
Sterling-Winthrop — First NDA Organization
- Jun 1, 1966
Sterling-Winthrop — NDA Organization
1970s
- Sep 15, 1978
Parke-Davis — Marketing Organization
- Sep 15, 1978
Warner Lambert — Marketing Organization
- Oct 23, 1979
Roxane Laboratories — Marketing Organization
- Oct 23, 1979
Boehringer Ingelheim — Marketing Organization
1980s
- Mar 30, 1981
Nephron Pharmaceuticals Corporation — Marketing Organization
- Jul 29, 1983
Baxalta — Marketing Organization
- Jul 29, 1983
Baxter — Marketing Organization
- Aug 21, 1984
Alpharma — Marketing Organization
1990s
- Jun 13, 1991
AstraZeneca — Marketing Organization
Indications
Approved for
Mechanism of action
- Beta-2 adrenergic receptorAGONIST
ADRB2 agonist
Approval history
- approvedJun 1, 1961
Chemistry & pharmacology
SMILES
CC[C@@H](NC(C)C)[C@@H](O)C1=CC=C(O)C(O)=C1- Mol. weight
- 239.3107 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
Yes
Sources
- WikipediaIsoetarine ↗
- NCATSYV0SN3276Q ↗
- ChEMBLCHEMBL1201213 ↗
- ChEMBLCHEMBL1201153 ↗
- ChEMBLCHEMBL1200920 ↗
Also known as
- beta-2
- beta-2
- bronchilator
- bronkometer
- bronkometer
- bronkosol
- bronkosol
- bronkosol
- etyprenaline
- etyprenaline
- etyprenaline
- isoctarine
- isoetarin
- isoetarina
- isoetarina
- isoetarine
- isoetarine
- isoetarine
- isoetarine
- isoetarine
- isoetarine hydrochloride
- isoetarine hydrochloride
- isoetarinum
- isoetarinum
- isoetharine
- isoetharine
- isoetharine
- isoetharine
- isoetharine
- isoetharine
- isoetharine hcl
- isoetharine hcl
- isoetharine hcl
- isoetharine hydrochloride
- isoetharine hydrochloride
- isoetharine hydrochloride
- isoetharine hydrochloride
- isoetharine hydrochloride s/f
- isoetharine hydrochloride s/f
- isoetharine mesilate
- isoetharine mesilate
- isoetharine mesilate
- isoetharine mesilate
- isoetharine mesilate
- isoetharine mesilate
- isoetharine mesylate
- isoetharine mesylate
- isoetharine mesylate
- isoetharine mesylate
- isoetharine mesylate salt
- isothurin
- numotac
- numotac
- win-3406
- win-3406
Organizations
Marketing (13)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Alpharma | For profit | MKTG | Aug 21, 1984 |
| AstraZeneca | For profit | MKTG | Jun 13, 1991 |
| Baxalta | For profit | MKTG | Jul 29, 1983 |
| Baxter | For profit | MKTG | Jul 29, 1983 |
| Boehringer Ingelheim | For profit | MKTG | Oct 23, 1979 |
| Dey | For profit | MKTG | — |
| International Medication | For profit | MKTG | — |
| Nephron Pharmaceuticals Corporation | For profit | MKTG | Mar 30, 1981 |
| Parke-Davis | For profit | MKTG | Sep 15, 1978 |
| Roxane Laboratories | For profit | MKTG | Oct 23, 1979 |
| Sanofi-Aventis | For profit | NDA2 | — |
| Sterling-Winthrop | For profit | NDA | Jun 1, 1966 |
| Warner Lambert | For profit | MKTG | Sep 15, 1978 |