gantacurium
Small moleculeexperimental
Gantacurium chloride is a new experimental neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Gantacurium is no longer in clinical development. — Wikipedia
Clinical trial activity
2 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2005 (NCT00235976)
Timeline
2000s
- Jan 1, 2005
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
Mechanism of action
- Muscarinic acetylcholine receptor M3INHIBITOR
GPM3 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COc1cc2c(cc1OC)[C@H](c1cc(OC)c(OC)c(OC)c1)[N@@+](C)(CCCOC(=O)/C=C(\Cl)C(=O)OCCC[N@+]1(C)CCc3cc(OC)c(OC)cc3[C@H]1Cc1cc(OC)c(OC)c(OC)c1)CC2- Mol. weight
- 993.59 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1182997 ↗
- WikipediaGantacurium chloride ↗
- ChEMBLCHEMBL275321 ↗
Also known as
- av430a
- av430a
- cw 002
- cw 002
- gantacurium
- gantacurium
- gantacurium
- gantacurium chloride
- gantacurium chloride
- gantacurium chloride
- gantacurium chloride
- gw280430a
- gw280430a
- gw280430a
- gw 280430a
- gw-280430a
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01338935 | Phase 1 | May 1, 2011 | Cornell University |
| NCT00235976 | Phase 1/Phase 2 (Phase 2) | May 1, 2005 | Avera Pharmaceuticals, Technical University of Munich |
Showing 2 of 2 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Avera Pharmaceuticals | For profit | 1 | 1 | 1 | 2005 |
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Technical University of Munich | Academic/Hospital | 1 | 0 | 1 | 2005 |
3 organizations
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