farampator
Small moleculeexperimental
Farampator is an ampakine drug. It was developed by Cortex Pharmaceuticals, and licensed to Organon BioSciences for commercial development. Following the purchase of Organon by Schering-Plough in 2007, the development license to farampator was transferred. The development of farampator was eventually terminated, reportedly due to concerns about cardiac toxicity. — Wikipedia
Clinical trial activity
3 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Mar 1, 2005 (NCT00262665)
Timeline
2000s
- Jan 1, 2005
Earliest Phase 2 Sponsor(trial)
Indications
Mechanism of action
- Glutamate receptor ionotropic AMPAPOSITIVE ALLOSTERIC MODULATOR
Glutamate receptor ionotropic AMPA positive allosteric modulator
Ampakine molecule.
Chemistry & pharmacology
Loading structure…
SMILES
O=C(c1ccc2nonc2c1)N1CCCCC1- Mol. weight
- 231.25 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaFarampator ↗
- ChEMBLCHEMBL1276138 ↗
Also known as
- 1-(benzofurazan-5-ylcarbonyl)piperidine
- 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole
- cx-691
- cx-691
- cx-691
- farampator
- farampator
- farampator
- org 24448
- org 24448
- org 24448
- org-24448
- org-24448
- sch 900460
- sch 900460
- sch-900460
- sch-900460
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00425815 | Phase 2 | Apr 1, 2009 | Columbia University, Duke University, Harvard University, New York University, University of California, Los Angeles, University of Maryland, Washington University in St. Louis |
| NCT00113022 | Phase 2 | May 1, 2005 | National Institute of Mental Health (NIMH) |
| NCT00262665 | Phase 2 | Mar 1, 2005 | Icahn School of Medicine at Mount Sinai, National Institutes of Health (NIH) |
Showing 3 of 3 trials
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Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Columbia University | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Duke University | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 1 | 1 | 2005 |
| National Institute of Mental Health (NIMH) | Government | 1 | 1 | 1 | 2005 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2005 |
| New York University | Academic/Hospital | 1 | 0 | 1 | 2009 |
| University of California, Los Angeles | Academic/Hospital | 1 | 1 | 1 | 2009 |
| University of Maryland | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Washington University in St. Louis | Academic/Hospital | 1 | 0 | 1 | 2009 |
10 organizations
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