duvoglustat
Small moleculeexperimental
1-Deoxynojirimycin, also called duvoglustat or moranolin, is an alpha-glucosidase inhibitor, most commonly found in mulberry leaves. Although it can be obtained in small quantities by brewing an herbal tea from mulberry leaves, interest in commercial production has led to research on developing mulberry tea higher in DNJ, and on alternate routes of production, such as via Bacillus species. — Wikipedia
Clinical trial activity
2 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2008 (NCT00688597)
Timeline
2000s
- Jan 1, 2008
Earliest Phase 2 Sponsor(trial)
Indications
Studied for
Mechanism of action
- Lysosomal alpha-glucosidaseSTABILISER
GAA stabiliser
Selectively and reversibly binds and stabilises the endogenous enzyme, facilitating proper protein folding and trafficking to lysosomes
Chemistry & pharmacology
Loading structure…
SMILES
OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O- Mol. weight
- 163.17 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL307429 ↗
- Wikipedia1-Deoxynojirimycin ↗
- ChEMBLCHEMBL460785 ↗
Also known as
- 1,5-deoxy-1,5-imino-d-mannitol
- 1,5-deoxy-1,5-imino-d-mannitol
- 1,5-dideoxy-1,5-imino-d-glucitol
- 1,5-dideoxy-1,5-imino-d-glucitol
- 1 deoxynojirimycin
- 1 deoxynojirimycin
- 1-deoxynojirimycin
- 1-deoxynojirimycin
- 1-deoxy-nojirimycin
- 1-deoxy-nojirimycin
- 5-amino-1,5-dideoxy-d-glucopyranose
- 5-amino-1,5-dideoxy-d-glucopyranose
- at2220
- at2220
- at2220
- at-2220
- at-2220
- d-1-deoxynojirimycin
- d-1-deoxynojirimycin
- deoxynojirimycin
- deoxynojirimycin
- deoxynojirimycin
- dnj
- dnj
- duvoglustat
- duvoglustat
- duvoglustat
- duvoglustat hcl
- duvoglustat hcl
- duvoglustat hydrochloride
- duvoglustat hydrochloride
- duvoglustat hydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01380743 | Phase 2 | Oct 1, 2011 | Amicus Therapeutics |
| NCT00688597 | Phase 2 | Nov 1, 2008 | Amicus Therapeutics |
Showing 2 of 2 trials
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Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Amicus Therapeutics | For profit | 2 | 2 | 1 | 2008 |
1 organizations
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