bi-2536
Small moleculeexperimental
Clinical trial activity
11 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
6
Phase 3
0
Phase 4
0
Earliest trial started Aug 1, 2004 (NCT02211859)
Timeline
Indications
Studied for
- Breast Neoplasms · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Carcinoma, Small Cell · Phase 2
- Endometrial Neoplasms · Phase 2
- Head and Neck Neoplasms · Phase 2
- Leukemia, Myeloid, Acute · Phase 2
- Lymphoma · Phase 1
- Melanoma · Phase 2
- Neoplasms · Phase 1
- Ovarian Neoplasms · Phase 2
- Pancreatic Neoplasms · Phase 2
- Prostatic Neoplasms · Phase 2
- Sarcoma · Phase 2
Mechanism of action
- Serine/threonine-protein kinase PLK1INHIBITOR
PLK1 inhibitor
Also potent inhibitor of PLK2 and PLK3.
Chemistry & pharmacology
Loading structure…
SMILES
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1- Mol. weight
- 521.67 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL513909 ↗
Also known as
- bi2536
- bi 2536
- bi 2536
- bi 2536
- bi-2536
- bi-2536
- bi-2536
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00526149 | Phase 2 | Jul 1, 2007 | European Organisation for Research and Treatment of Cancer, Katholieke Universiteit Leuven |
| NCT02215044 | Phase 1 | Jun 1, 2007 | Boehringer Ingelheim |
| NCT00412880 | Phase 2 | Jan 1, 2007 | Boehringer Ingelheim |
| NCT02211833 | Phase 1 | Oct 1, 2006 | Boehringer Ingelheim |
| NCT00701766 | Phase 2 | Oct 1, 2006 | Boehringer Ingelheim |
| NCT00706498 | Phase 2 | Sep 1, 2006 | Boehringer Ingelheim |
| NCT00710710 | Phase 2 | Aug 1, 2006 | Boehringer Ingelheim |
| NCT00376623 | Phase 2 | Jul 1, 2006 | Boehringer Ingelheim |
| NCT00243087 | Phase 1 | Jul 1, 2005 | Boehringer Ingelheim, University of Nebraska |
| NCT02211859 | Phase 1 | Aug 1, 2004 | Boehringer Ingelheim |
| NCT02211872 | Phase 1 | Aug 1, 2004 | Boehringer Ingelheim |
Showing 11 of 11 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Boehringer Ingelheim | For profit | 10 | 10 | 2 | 2004 |
| European Organisation for Research and Treatment of Cancer | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Katholieke Universiteit Leuven | Academic/Hospital | 1 | 0 | 1 | 2007 |
| University of Nebraska | Academic/Hospital | 1 | 0 | 1 | 2005 |
4 organizations
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