r-428
Small moleculeexperimental
Clinical trial activity
4 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Sep 1, 2014 (NCT02488408)
Timeline
2010s
- Jan 1, 2014
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Tyrosine-protein kinase receptor UFOINHIBITOR
AXL inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Nc1nc(Nc2ccc3c(c2)CCC(N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2- Mol. weight
- 506.66 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2023349 ↗
Also known as
- bgb324
- bgb324
- bgb-324
- bgb-324
- cs-1046
- cs-1046
- hy-15150
- hy-15150
- kb-80319
- kb-80319
- qc-11751
- qc-11751
- r428
- r428
- r-428
- r-428
- r-428
- syn-1131
- syn-1131
- w-5845
- w-5845
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02872259 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2017 | BerGenBio ASA, University of Bergen |
| NCT02922777 | Phase 1 | Nov 1, 2016 | BerGenBio ASA, Texas Tech University, The University of Texas, Dallas |
| NCT02424617 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2015 | BerGenBio ASA, Chiltern International, University of Texas at Houston |
| NCT02488408 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2014 | BerGenBio ASA, University of Hamburg |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| BerGenBio ASA | For profit | 4 | 2 | 2 | 2014 |
| Chiltern International | For profit | 1 | 0 | 1 | 2015 |
| Texas Tech University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| The University of Texas, Dallas | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Bergen | Academic/Hospital | 1 | 1 | 1 | 2017 |
| University of Hamburg | Academic/Hospital | 1 | 0 | 1 | 2014 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2015 |
7 organizations
Page 1 / 1