belladonna
Belladonna or Bella Donna may refer to: — Wikipedia
Clinical trial activity
8 trials · 9 clinical orgs · 0 marketing orgs
Earliest trial started Mar 17, 2009 (NCT00863928)
Timeline
2010s
- Jan 1, 2019
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Unknown
Scientific evidence to recommend the use of A. belladonna in its natural form for any condition is insufficient, although some of its components, in particular l-atropine, which was purified from belladonna in the 1830s, have accepted medical uses. Donnatal is a pharmaceutical prescription, approved in the United States by the FDA, that combines natural belladonna alkaloids (atropine and scopolamine) in a specific, fixed ratio with phenobarbital to provide peripheral anticholinergic/antispasmodic action and mild sedation. According to its labeling, it is possibly effective for use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.
- Unspecified targetUnclear
unclear
Scientific evidence to recommend the use of A. belladonna in its natural form for any condition is insufficient, although some of its components, in particular l-atropine, which was purified from belladonna in the 1830s, have accepted medical uses. Donnatal is a pharmaceutical prescription, approved in the United States by the FDA, that combines natural belladonna alkaloids (atropine and scopolamine) in a specific, fixed ratio with phenobarbital to provide peripheral anticholinergic/antispasmodic action and mild sedation. According to its labeling, it is possibly effective for use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBelladonna ↗
- NCATSWQZ3G9PF0H ↗
- ChEMBLCHEMBL2108906 ↗
- ChEMBLCHEMBL2108834 ↗
- NCATS6MW97Q6E8M ↗
- NCATS6GZW20TIOI ↗
Also known as
- bellad
- belladonna
- belladonna
- belladonna
- belladonna
- belladonna extract
- belladonna root
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03753776 | Phase 3 | Jun 1, 2019 | Institut de Cancérologie de la Loire (ICLN), Institut de Cancérologie Lucien Neuwirth |
| NCT02865395 | Phase 4 | Mar 1, 2016 | George Washington University |
| NCT02600715 | Phase 4 | Nov 1, 2015 | University of Kansas |
| NCT02291042 | N/A | Oct 1, 2015 | Southern New Hampshire Medical Center |
| NCT03332056 | Phase 4 | Aug 31, 2013 | University of Washington |
| NCT01150474 | Phase 4 | Jan 1, 2011 | Mayo Clinic |
| NCT01271855 | Phase 4 | May 1, 2009 | Loyola University |
| NCT00863928 | N/A | Mar 17, 2009 | Virginia Mason Medical Center |
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| George Washington University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Institut de Cancérologie de la Loire (ICLN) | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Institut de Cancérologie Lucien Neuwirth | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Loyola University | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Southern New Hampshire Medical Center | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Kansas | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Washington | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Virginia Mason Medical Center | Academic/Hospital | 1 | 1 | 1 | 2009 |