kappadione

Small moleculeapproved

Approved

Jul 15, 1941

Kappadione is a vitamin K derivative used for the treatment of side effects of vitamin K antagonists such as warfarin, prophylaxis and treatment of vitamin K deficiency bleeding, and hypoprothrombinemia due to various causes. It was manufactured by Eli Lilly and Company. Chemically, it is menadiol sodium diphosphate. It was approved by the US Food and Drug Administration prior to 1982 and marketed by Lilly. It has since been discontinued and is not available in North America. — Wikipedia

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1940s

  1. Jul 15, 1941

    Roche — Earliest FDA Approval

  2. Jul 15, 1941

    Roche — NDA Organization

Indications

Mechanism of action

Approval history

  • approvedJul 15, 1941

Chemistry & pharmacology

Loading structure…

SMILES

Cc1cc(OP(=O)([O-])[O-])c2ccccc2c1OP(=O)([O-])[O-].O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+]
Mol. weight
530.18 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Oral, Parenteral
Availability
Discontinued

Oral

Yes

Parenteral

Yes

Topical

No

Sources

Also known as

  • 2-methyl-1,4-naphthalenediol
  • 2-methyl-1,4-naphthohydroquinone
  • 2-methyl-1,4-naphthoquinol
  • acetomenaphthone
  • acetomenaphthone
  • acetomenaphtone
  • acetomenaphtone
  • dihydrovitamin k3
  • dihydrovitamin k3
  • dihydrovitamin k3
  • dihydrovitamin k3
  • dihydrovitamin k3
  • kapilon
  • kapilon
  • kapilon
  • kappadione
  • kappadione
  • kappadione
  • kappadione
  • kappadione
  • kappaxan
  • kappaxan
  • menadiol
  • menadiol
  • menadiol
  • menadiol
  • menadiol
  • menadiol
  • menadiol, (-1)-ion
  • menadiol diphosphate
  • menadiol diphosphate ion
  • menadiol diphosphate, monosodium salt
  • menadiol diphosphate, tetrasodium salt
  • menadiol disodium disulfate
  • menadiol, monopotassium salt
  • menadiol potassium sulfate
  • menadiol sodium diphosphate
  • menadiol sodium diphosphate
  • menadiol sodium diphosphate
  • menadiol sodium diphosphate
  • menadiol sodium diphosphate
  • menadiol sodium diphosphate
  • menadiol sodium diphosphate
  • menadiol sodium diphosphate hexahydrate
  • menadiol sodium phosphate
  • menadiol sodium sulfate
  • menadiol sulfate
  • menadoxime
  • naphtadon
  • potassium menaphthosulfate
  • reduced menadione
  • synkavit
  • synkavit
  • synkavit
  • synkavite
  • synkayvite
  • synkayvite
  • synkayvite
  • vitamin k 4

Organizations

Marketing (2)

OrganizationOrg typeRelationshipDate
Eli LillyFor profitNDA2
RocheFor profitNDAJul 15, 1941