sulfathiazole

Small moleculeapproved

Approved

Jul 1, 1940

Sulfathiazole is a short-acting sulfonamide with properties similar to those of sulfamethoxazole. It is now rarely used systemically due to its toxicity. Sulfathiazole is used with other sulfonamides, usually sulfabenzamide and sulfacetamide, in preparations for the topical treatment of vaginal infections and is also used with other drugs in the treatment of skin infections. Sulfathiazole sodium has been applied topically with other drugs in the treatment of eye infections. Sulfathiazole interferes with nucleic acid synthesis in microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid.It has properties similar to sulfamethoxazole. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 9 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1940s

Jul 1, 1940
Earliest FDA Approval
Sep 12, 1945
Johnson and Johnson — First NDA Organization
Sep 12, 1945
Johnson and Johnson — NDA Secondary Org
Sep 12, 1945
Johnson and Johnson — NDA Organization

1980s

Jul 23, 1982
Savage Labs — Marketing Organization
Nov 15, 1982
Perrigo — Marketing Organization
Nov 15, 1982
Padagis Us — Marketing Organization
Jun 9, 1986
ACP Nimble — Marketing Organization
Jun 9, 1986
Cosette — Marketing Organization

Indications

Approved for

Vaginitis

Mechanism of action

Bacterial dihydropteroate synthaseINHIBITOR
folP inhibitor
- Dihydropteroate synthase (folP) ↗

Combination products

triple sulfa
with sulfacetamide, sulfabenzamide

Approval history

approvedJul 1, 1940

Chemistry & pharmacology

Loading structure…

SMILES

NC1=CC=C(C=C1)S(=O)(=O)NC2=NC=CS2

Mol. weight: 255.317 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Topical

Oral

Parenteral

Topical

Yes

Sources

Also known as

2-(p-aminobenzenesulfonamido)thiazole
2-(p-aminobenzenesulfonamido)thiazole
2-(p-aminobenzenesulphonamido)thiazole
2-(p-aminobenzenesulphonamido)thiazole
2-sulfanilamidothiazol
2-sulfanilamidothiazol
2-sulfanilamidothiazole
2-sulfanilamidothiazole
2-(sulfanilylamino)thiazole
2-(sulfanilylamino)thiazole
2-sulfonamidothiazole
2-sulfonamidothiazole
4-amino-n-2-thiazolylbenzenesulfonamide
4-amino-n-2-thiazolylbenzenesulfonamide
alphadol
n(1)-2-thiazolylsulfanilamide
n(1)-2-thiazolylsulfanilamide
n(1)-2-thiazolylsulfanilamide
n1-2-thiazolylsulfanilamide
n1-2-thiazolylsulfanilamide
norsulfasol
norsulfazol
norsulfazole
norsulfazole
sulfanilamidothiazole
sulfanilamidothiazole
sulfanilamidothiazole
sulfathiazol
sulfathiazol
sulfathiazol
sulfathiazole
sulfathiazole
sulfathiazole
sulfathiazole
sulfathiazole
sulfathiazole
sulfathiazole
sulfathiazole
sulfathiazole
sulfathiazole
sulfathiazole, monosodium salt
sulfathiazole (triple sulfa)
sulfathiazole (triple sulfa)
sulfathiazolum
sulfathiazolum
sulfatiazol
sulfatiazol
sulphathiazole
sulphathiazole
sulphathiazole
sulphathiazole
thiazamide
thiazamide
thiozamide

Organizations

Marketing (10)

Organization	Org type	Relationship	Date
ACP Nimble	For profit	MKTG	Jun 9, 1986
Alpharma	For profit	MKTG	—
Cosette	For profit	MKTG	Jun 9, 1986
Fougera	For profit	MKTG	—
Johnson and Johnson	For profit	NDA2	Sep 12, 1945
Johnson and Johnson	For profit	NDA	Sep 12, 1945
Padagis Us	For profit	MKTG	Nov 15, 1982
Perrigo	For profit	MKTG	Nov 15, 1982
Pharmaderm	For profit	MKTG	—
Savage Labs	For profit	MKTG	Jul 23, 1982