hydrocortamate

Trade name: magnacort

Small moleculeapproved

Approved

Oct 15, 1956

Hydrocortamate is a synthetic glucocorticoid possessing anti-inflammatory properties and acting as a glucocorticoid receptor agonist. Hydrocortamate was used under the brand name Magnacor to treat inflammation due to corticosteroid-responsive dermatoses btut that usage has been discontinued. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1950s

Oct 15, 1956
Pfizer — Earliest FDA Approval
Oct 15, 1956
Pfizer — NDA Organization

Indications

Approved for

Skin Diseases

Mechanism of action

Glucocorticoid receptorAGONIST
NR3C1 agonist
- Glucocorticoid receptor (NR3C1) ↗

Approval history

approvedOct 15, 1956

Chemistry & pharmacology

Loading structure…

SMILES

CCN(CC)CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

Mol. weight: 475.63 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Topical
Availability: Discontinued

Oral

Parenteral

Topical

Yes

Sources

Also known as

17-hydroxycorticosterone, 21-(diethylamino)acetate
17-hydroxycorticosterone, 21-(diethylamino)acetate
ethamicort
hidrocortamato
hidrocortamato
hydrocortamate
hydrocortamate
hydrocortamate
hydrocortamate
hydrocortamate
hydrocortamate
hydrocortamate
hydrocortamate chloride
hydrocortamate chloride
hydrocortamate hcl
hydrocortamate hcl
hydrocortamate hcl
hydrocortamate hydrochloride
hydrocortamate hydrochloride
hydrocortamate hydrochloride
hydrocortamate hydrochloride
hydrocortamatum
hydrocortamatum
magnacort
magnacort
magnacort
magnacort

Organizations

Marketing (1)

Organization	Org type	Relationship	Date
Pfizer	For profit	NDA	Oct 15, 1956