fluprednisolone

Trade name: alphadrol

Small moleculeapproved

Approved

Jun 1, 1960

Fluprednisolone is glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated (hypersensitivity dermatoses, contact dermatitis, pemphigus, pemphigoid, lupus erythematosus, neoplasia etc), except adrenal deficiency states. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1960s

Jun 1, 1960
Earliest FDA Approval

1970s

Oct 24, 1978
Pharmacia & Upjohn — First NDA Organization
Oct 24, 1978
Pharmacia & Upjohn — NDA Secondary Org
Oct 24, 1978
Pharmacia & Upjohn — NDA Organization

Indications

Approved for

Mechanism of action

Glucocorticoid receptorAGONIST
NR3C1 agonist
- Glucocorticoid receptor (NR3C1) ↗

Approval history

approvedJun 1, 1960

Chemistry & pharmacology

Loading structure…

SMILES

C[C@]12C[C@H](O)[C@H]3[C@@H](C[C@H](F)C4=CC(=O)C=C[C@]34C)[C@@H]1CC[C@]2(O)C(=O)CO

Mol. weight: 378.4345 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Discontinued

Oral

Yes

Parenteral

Topical

Sources

Also known as

alphadrol
alphadrol
alphadrol
alphadrol
etadrol
fluprednisolone
fluprednisolone
fluprednisolone
fluprednisolone
fluprednisolone
fluprednisolone
fluprednisolone
fluprednisolone
fluprednisolone
u-7800
u-7800

Organizations

Marketing (2)

Organization	Org type	Relationship	Date
Pharmacia & Upjohn	For profit	NDA2	Oct 24, 1978
Pharmacia & Upjohn	For profit	NDA	Oct 24, 1978