flumethasone
Trade name: locorten
Flumethasone or flumetasone is a corticosteroid and is an agonist of a glucocorticoid receptor with anti-inflammatory, antipruritic and vasoconstrictive properties. Flumethasone is often formulated as the pivalic acid ester, flumetasone pivalate. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin. Flumethasone is used for the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin condition. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Timeline
Indications
Approved for
Mechanism of action
- Glucocorticoid receptorAGONIST
NR3C1 agonist
Approval history
- approved—
Chemistry & pharmacology
SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO- Mol. weight
- 410.4515 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
Yes
Sources
- WikipediaFlumetasone ↗
- NCATSLR3CD8SX89 ↗
- ChEMBLCHEMBL1201392 ↗
- ChEMBLCHEMBL1200877 ↗
Also known as
- 6 alpha,9 alpha-difluoro-11 beta,17,21-trihydroxy-16 alpha-methylpregna-1,4-diene-3,20-dione, 21-pivalate
- 6alpha,9-difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
- 6alpha,9-difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
- cerson
- flucorticin
- flumetasona
- flumetasona
- flumetasone
- flumetasone
- flumetasone
- flumetasone
- flumetasone
- flumetasone
- flumetasone
- flumétasone
- flumétasone
- flumetasone pivalate
- flumetasone pivalate
- flumetasone pivalate
- flumetasone pivalate
- flumetasonum
- flumetasonum
- flumethason
- flumethasone
- flumethasone
- flumethasone
- flumethasone
- flumethasone
- flumethasone 21-pivalate
- flumethasone dimethylpropionate
- flumethasone pivalate
- flumethasone pivalate
- flumethasone pivalate
- flumethasone pivalate
- flumethasone pivalate
- flumethasone pivalate
- flumethasone pivalate
- fluorodexamethazone
- locacorten
- locacorten
- locacorten-vioform
- locorten
- locorten
- locorten
- locorten
- locorten
- locorten-vioform
- locorten-vioform
- locorten-vioform
- novartis brand of flumethasone pivalate