ethopropazine

Trade name: parsidol

Small moleculeapproved

Ethopropazine is an anticholinergic drug. Ethopropazine is an inhibitor of butyrylcholinesterase and non-selective muscarinic acetylcholine receptor antagonist. Ethopropazine has been used for the treatment of parkinsonism and drug-induced extrapyramidal reactions. Also It used for the symptomatic treatment of hepatolenticular degeneration and congenital athetosis. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 2 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1950s

Jun 1, 1953
Rhone Poulenc — First NDA Organization
Jun 1, 1953
Rhone Poulenc — NDA Organization

Indications

Approved for

Mechanism of action

Muscarinic acetylcholine receptor M1ANTAGONIST
CHRM1 antagonist
Indicated for Parkinson's disease, M1 likely responsible
- Muscarinic acetylcholine receptor M1 (CHRM1) ↗

Approval history

approved—

Chemistry & pharmacology

Loading structure…

SMILES

CCN(CC)C(C)CN1c2ccccc2Sc2ccccc21

Mol. weight: 312.48 g/mol
Lipinski Ro5: 1 violation(s)
Rule of 3: No
Chirality: Racemic Mixture
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Discontinued

Oral

Yes

Parenteral

Topical

Sources

Also known as

10-[2-(diethylamino)-1-propyl]phenothiazine
10-[2-(diethylamino)-1-propyl]phenothiazine
10-[2-(diethylamino)-2-methylethyl]phenothiazine
10-[2-(diethylamino)-2-methylethyl]phenothiazine
10-(2-diethylaminopropyl)phenothiazine
10-(2-diethylaminopropyl)phenothiazine
10-[2-(diethylamino)propyl]phenothiazine
10-[2-(diethylamino)propyl]phenothiazine
10h-phenothiazine-10-ethanamine, n,n-diethyl-alpha-methyl-
2-diethylamino-1-propyl-n-dibenzoparathiazine
2-diethylamino-1-propyl-n-dibenzoparathiazine
ethapropazine
ethopromazine
ethopropazine
ethopropazine
ethopropazine
ethopropazine
ethopropazine
ethopropazine
ethopropazine
ethopropazine
ethopropazine hcl
ethopropazine hcl
ethopropazine hcl
ethopropazine hydrochloride
ethopropazine hydrochloride
ethopropazine hydrochloride
ethopropazine hydrochloride
ethopropazine hydrochloride
isopthazine
isothazine
isothiazine
lysivane
n,n-diethyl-1-(10h-phenothiazin-10-yl)-2-propanamine
n,n-diethyl-1-(10h-phenothiazin-10-yl)-2-propanamine
n,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethanamine
n,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethanamine
parsidol
parsidol
parsidol
parsidol
parsitan
profenamina
profenamina
profenamine
profenamine
profenamine
profenamine
profenamine
profenamine
profenamine hcl
profenamine hcl
profenamine hibenzate
profenamine hibenzate
profenamine hibenzate
profenamine hibenzate
profenamine hibenzate
profenamine hydrochloride
profenamine hydrochloride
profenaminum
profenaminum
prophenamine hcl
prophenamine hcl

Organizations

Marketing (2)

Organization	Org type	Relationship	Date
Parke-Davis	For profit	NDA2	—
Rhone Poulenc	For profit	NDA	Jun 1, 1953