estropipate
Trade name: ogen
Approved
May 19, 1977
Estropipate, also known as piperazine estrone sulfate and sold under the brand names Harmogen, Improvera, Ogen, Ortho-Est, and Sulestrex among others, is an estrogen medication which is used mainly in menopausal hormone therapy in the treatment of menopausal symptoms. It is a salt of estrone sulfate and piperazine, and is transformed into estrone and estradiol in the body. It is taken by mouth. — Wikipedia
Clinical trial activity
0 trials · 0 clinical orgs · 9 marketing orgs
Timeline
1970s
- May 19, 1977
Earliest FDA Approval
- May 19, 1977
Pharmacia & Upjohn — Marketing Organization
- May 19, 1977
Pfizer — Marketing Organization
- Jun 3, 1977
Pharmacia & Upjohn — First NDA Organization
- Jun 3, 1977
Pharmacia & Upjohn — NDA Organization
1990s
- Feb 27, 1991
Sun Pharmaceuticals — Marketing Organization
- Sep 23, 1993
Watson Pharmaceuticals — Marketing Organization
- Sep 23, 1993
Teva — Marketing Organization
- Nov 27, 1996
Barr Laboratories — Marketing Organization
- Aug 26, 1999
Mylan — Marketing Organization
- Aug 26, 1999
PHARMOBEDIENT — Marketing Organization
- Nov 1, 1999
Duramed Research — Marketing Organization
Indications
Approved for
Mechanism of action
- Estrogen receptorAGONIST
ESR1 agonist
Approval history
- approvedMay 19, 1977
Chemistry & pharmacology
SMILES
C1CNCCN1.C[C@]12CC[C@@H]3c4ccc(OS(=O)(=O)O)cc4CC[C@H]3[C@@H]1CCC2=O- Mol. weight
- 436.57 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral, Topical
- Availability
- Prescription Only
Oral
Yes
Parenteral
No
Topical
Yes
Sources
- WikipediaEstropipate ↗
- ChEMBLCHEMBL1200980 ↗
Also known as
- estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, compd. with piperazine (1:1)
- estropipate
- estropipate
- estropipate
- estropipate
- estropipate
- estropipate
- genoral
- harmogen
- harmogen
- harmogen
- harmonet
- ogen
- ogen
- ogen
- ogen 1.25
- ogen 1.25
- ogen 2.5
- ogen 2.5
- ogen 5
- ogen 5
- ogen .625
- ogen .625
- ortho-est
- ortho-est
- ortho-est
- piperazine estrone sulfate
- piperazine estrone sulfate
- piperazine estrone sulfate
- piperazine estrone sulfate
Organizations
Marketing (10)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Barr Laboratories | For profit | MKTG | Nov 27, 1996 |
| Duramed Research | For profit | MKTG | Nov 1, 1999 |
| Mylan | For profit | MKTG | Aug 26, 1999 |
| PHARMOBEDIENT | For profit | MKTG | Aug 26, 1999 |
| Pfizer | For profit | MKTG | May 19, 1977 |
| Pharmacia & Upjohn | For profit | MKTG | May 19, 1977 |
| Pharmacia & Upjohn | For profit | NDA | Jun 3, 1977 |
| Sun Pharmaceuticals | For profit | MKTG | Feb 27, 1991 |
| Teva | For profit | MKTG | Sep 23, 1993 |
| Watson Pharmaceuticals | For profit | MKTG | Sep 23, 1993 |