dienestrol
Approved
Jan 9, 1947
Dienestrol (INN, USAN) (brand names Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol, numerous others) is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of the vulva. Conditions that are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis). Dienestrol currently discontinued in US, but still in market in some other counties — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 3 marketing orgs
Timeline
1940s
- Jan 9, 1947
Johnson and Johnson — Earliest FDA Approval
- Jan 9, 1947
Johnson and Johnson — NDA Secondary Org
- Jan 9, 1947
Johnson and Johnson — NDA Organization
1970s
- Nov 4, 1975
Solvay — Marketing Organization
Indications
Mechanism of action
- Estrogen receptor alphaAGONIST
ESR1 agonist
Approval history
- approvedJan 9, 1947
Chemistry & pharmacology
SMILES
C\C=C(C1=CC=C(O)C=C1)\C(=C\C)C2=CC=C(O)C=C2- Mol. weight
- 266.3343 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
Yes
Sources
- WikipediaDienestrol ↗
- NCATSRRW32X4U1F ↗
- ChEMBLCHEMBL1018 ↗
Also known as
- alpha-dienestrol diacetate
- alpha-dienestrol diacetate
- cycladiene
- cycladiene
- cycladiene
- dehydrostilbestrol
- dehydrostilbestrol
- dienesterol
- dienestrol
- dienestrol
- dienestrol
- dienestrol
- dienestrol
- dienestrol
- dienestrol
- dienestrol
- dienestrol
- dienestrol
- dienestrol
- diènestrol
- diènestrol
- dienestrolum
- dienestrolum
- dienoestrol
- dv
- dv
- dv
- estraguard
- estraguard
- estrodienol
- follidiene
- hormofemin
- hormofemin
- oestrodiene
- synestrol
Organizations
Marketing (4)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Johnson and Johnson | For profit | NDA2 | Jan 9, 1947 |
| Johnson and Johnson | For profit | NDA | Jan 9, 1947 |
| Sanofi-Aventis | For profit | MKTG | — |
| Solvay | For profit | MKTG | Nov 4, 1975 |