dienestrol

Small moleculeapproved

Approved

Jan 9, 1947

Dienestrol (INN, USAN) (brand names Ortho Dienestrol, Dienoestrol, Dienoestrol Ortho, Sexadien, Denestrolin, Dienol, Dinovex, Follormon, Oestrodiene, Synestrol, numerous others) is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of the vulva. Conditions that are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis). Dienestrol currently discontinued in US, but still in market in some other counties — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 3 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1940s

  1. Jan 9, 1947

    Johnson and Johnson — Earliest FDA Approval

  2. Jan 9, 1947

    Johnson and Johnson — NDA Secondary Org

  3. Jan 9, 1947

    Johnson and Johnson — NDA Organization

1970s

  1. Nov 4, 1975

    Solvay — Marketing Organization

Indications

Mechanism of action

Approval history

  • approvedJan 9, 1947

Chemistry & pharmacology

Loading structure…

SMILES

C\C=C(C1=CC=C(O)C=C1)\C(=C\C)C2=CC=C(O)C=C2
Mol. weight
266.3343 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Topical
Availability
Discontinued

Oral

No

Parenteral

No

Topical

Yes

Sources

Also known as

  • alpha-dienestrol diacetate
  • alpha-dienestrol diacetate
  • cycladiene
  • cycladiene
  • cycladiene
  • dehydrostilbestrol
  • dehydrostilbestrol
  • dienesterol
  • dienestrol
  • dienestrol
  • dienestrol
  • dienestrol
  • dienestrol
  • dienestrol
  • dienestrol
  • dienestrol
  • dienestrol
  • dienestrol
  • dienestrol
  • diènestrol
  • diènestrol
  • dienestrolum
  • dienestrolum
  • dienoestrol
  • dv
  • dv
  • dv
  • estraguard
  • estraguard
  • estrodienol
  • follidiene
  • hormofemin
  • hormofemin
  • oestrodiene
  • synestrol

Organizations

Marketing (4)

OrganizationOrg typeRelationshipDate
Johnson and JohnsonFor profitNDA2Jan 9, 1947
Johnson and JohnsonFor profitNDAJan 9, 1947
Sanofi-AventisFor profitMKTG
SolvayFor profitMKTGNov 4, 1975