cyclopropane

Small moleculemarketed

Approved

Jun 1, 1929

Cyclopropane is a cycloalkane, consisting of three carbon atoms, linked to each other to form a ring. Cyclopropane was used as an anesthetic gas since the 1920s, due to being non-irritant, giving rapid induction, excellent relaxation, quiet respiration, and speedy recovery. However, the prolonged administration of cyclopropane may induce a reaction known as "cyclopropane shock", which manifests in a sudden decrease in blood pressure, potentially leading to cardiac dysrhythmia. Because of the toxicity and extreme flammability, cyclopropane was used only for the induction of anesthesia and was gradually superseded by more safe anesthetics. Cyclopropane works by blocking NMDA and AMPA receptors and activating K2P channels, kainate ion channels and glycine receptors at clinical concentrations. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Timeline

1920s

  1. Jun 1, 1929

    Evidence of US Marketing

Indications

Mechanism of action

Approval history

  • approvedJun 1, 1929

Chemistry & pharmacology

Loading structure…

SMILES

C1CC1
Mol. weight
42.0797 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • cyclopropane
  • cyclopropane
  • cyclopropane
  • trimethylene

Organizations

Marketing (1)

OrganizationOrg typeRelationshipDate
SquibbFor profitNDA