cefonicid
Small moleculeapproved
Approved
Jul 26, 1993
Cefonicid is a semi-synthetic broad-spectrum cephalosporin antibiotic resistant to beta-lactamases. Similarly to other cephalosporins, cefonicid exerts its antibacterial activity through the inhibition of the bacterial cell-wall synthesis. Its in vitro and in vivo activity against a wide range of Gram-positive and Gram-negative microorganisms is documented. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1990s
- Jul 26, 1993
Earliest FDA Approval
- Jul 26, 1993
GlaxoSmithKline — Marketing Organization
Indications
Approved for
Mechanism of action
- Bacterial penicillin-binding proteinINHIBITOR
Bacterial penicillin-binding protein inhibitor
- D-alanyl-D-alanine carboxypeptidase DacB (dacB) ↗
- Peptidoglycan D,D-transpeptidase FtsI (ftsI) ↗
- Penicillin-binding protein 1A (mrcA) ↗
- Penicillin-binding protein 1B (mrcB) ↗
- D-alanyl-D-alanine carboxypeptidase DacA (dacA) ↗
- Peptidoglycan D,D-transpeptidase MrdA (mrdA) ↗
- D-alanyl-D-alanine carboxypeptidase DacC (dacC) ↗
Approval history
- approvedJul 26, 1993
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)C1=C(CSc2nnnn2CS(=O)(=O)O)CS[C@@H]2[C@H](NC(=O)[C@H](O)c3ccccc3)C(=O)N12- Mol. weight
- 542.58 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Discontinued
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL1601 ↗
- WikipediaCefonicid ↗
- NCATS6532B86WFG ↗
- ChEMBLCHEMBL1201005 ↗
Also known as
- (6r,7r)-7-{[(2r)-2-hydroxy-2-phenylacetyl]amino}-8-oxo-3-({[1-(sulfomethyl)-1h-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- (6r,7r)-7-{[(2r)-2-hydroxy-2-phenylacetyl]amino}-8-oxo-3-({[1-(sulfomethyl)-1h-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- cefonicid
- cefonicid
- cefonicid
- cefonicid
- cefonicid
- cefonicid
- cefonicid
- cefonicid
- cefonicido
- cefonicido
- cefonicid sodium
- cefonicid sodium
- cefonicid sodium
- cefonicid sodium
- cefonicidum
- cefonicidum
- monocid
- monocid
- monocid
- monocid
- monocid
- monocid
- monocid
- sk&f-d-75073-z2
- sk&f-d-75073-z2
Organizations
Marketing (3)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| GlaxoSmithKline | For profit | MKTG | Jul 26, 1993 |
| GlaxoSmithKline | For profit | NDA2 | — |
| SmithKline Beckman | For profit | NDA | — |