buclizine

Small moleculeapproved

Approved

Apr 8, 1957

Buclizine, a piperazine derivative, is a sedating antihistamine with antimuscarinic and moderate sedative action. The drug is used mainly for its antiemetic action, particularly in the prevention of motion sickness, and in the treatment of migraine in combination with analgesics. The following side/adverse effects have been selected on the basis of their potential clinical significance: drowsiness; Incidence less frequent; blurred vision; dryness of mouth, nose, and throat; headache; nervousness, restlessness, or trouble in sleeping; upset stomach. The following drug interactions have been selected on the basis of their potential clinical significance: alcohol; anticholinergics or other medications with anticholinergic activity; apomorphine. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1950s

Apr 8, 1957
Stuart Pharmaceuticals — Earliest FDA Approval
Apr 8, 1957
Stuart Pharmaceuticals — NDA Secondary Org
Apr 8, 1957
Stuart Pharmaceuticals — NDA Organization

Indications

Approved for

Mechanism of action

Histamine H1 receptorANTAGONIST
HRH1 antagonist
- Histamine H1 receptor (HRH1) ↗

Approval history

approvedApr 8, 1957

Chemistry & pharmacology

Loading structure…

SMILES

CC(C)(C)c1ccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1

Mol. weight: 433.04 g/mol
Lipinski Ro5: 1 violation(s)
Rule of 3: No
Chirality: Racemic Mixture
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Discontinued

Oral

Yes

Parenteral

Topical

Sources

Also known as

1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)piperazine
1-(p-tert-butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine
1-(p-tert-butylbenzyl)-4-(4-chloro-alpha-phenylbenzyl)piperazine
aphilan
bucladin
bucladin
bucladin
bucladin-s
bucladin-s
bucladin-s
buclifen
buclizina
buclizina
buclizine
buclizine
buclizine
buclizine
buclizine
buclizine
buclizine
buclizine
buclizine
buclizine
buclizine dihydrochloride
buclizine hcl
buclizine hcl
buclizine hcl
buclizine hydrochloride
buclizine hydrochloride
buclizine hydrochloride
buclizine hydrochloride
buclizine hydrochloride
buclizinum
buclizinum
cyclizine hydrochloride
cyclizine hydrochloride
cyclizine hydrochloride
equivert
histabuticine
histabutizine
histabutyzine
hitabutyzyne
softran
stuart brand 1 of buclizine dihydrochloride
stuart brand 2 of buclizine dihydrochloride
ucb-4445
ucb-4445

Organizations

Marketing (2)

Organization	Org type	Relationship	Date
Stuart Pharmaceuticals	For profit	NDA2	Apr 8, 1957
Stuart Pharmaceuticals	For profit	NDA	Apr 8, 1957