d-limonene
Small moleculeexperimental
Limonene is a colorless liquid aliphatic hydrocarbon classified as a cyclic monoterpene, and is the major component in the essential oil of citrus fruit peels. The (+)-isomer, occurring more commonly in nature as the fragrance of oranges, is a flavoring agent in food manufacturing. It is also used in chemical synthesis as a precursor to carvone and as a renewables-based solvent in cleaning products. The less common (−)-isomer has a piny, turpentine-like odor, and is found in the edible parts of such plants as caraway, dill, and bergamot orange plants. — Wikipedia
Clinical trial activity
5 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Aug 1, 2009 (NCT01046929)
Timeline
Indications
Mechanism of action
- Unspecified targetUnclear
Unclear
- Unspecified target
solvent
Chemistry & pharmacology
Loading structure…
SMILES
C=C(C)[C@H]1CC=C(C)CC1- Mol. weight
- 136.24 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLimonene ↗
- ChEMBLCHEMBL449062 ↗
Also known as
- 1-methyl-4-(1-methylethenyl)cyclohexene
- 4-mentha-1,8-diene
- (4r)-1-methyl-4-(1-methylethenyl)cyclohexene
- (4s)-1-methyl-4-isopropenylcyclohex-1-ene
- aisa 5203-l (+)limonene
- cyclohexene, 1-methyl-4-(1-methylethenyl)-, (4r)-
- dipentene
- (d)-limonene
- d-limonene
- d-limonene
- d-limonene
- d-limonene
- limonene
- limonene
- limonene
- (-)-limonene
- (+)-limonene
- limonene, (+)-
- limonene, (+-)-isomer
- limonene, (r)-isomer
- limonene, (s)-isomer
- (+)-(r)-4-isopropenyl-1-methylcyclohexene
- (r)-4-isopropenyl-1-methylcyclohexene
- (r)-(+)-limonene
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04392622 | Phase 1 | Nov 30, 2020 | Stanford University |
| NCT04484467 | N/A | Feb 9, 2018 | Government of Russia, I.M. Sechenov First Moscow State Medical University |
| NCT04296266 | Early Phase 1 (Phase 1) | Feb 29, 2016 | Stanford University |
| NCT01654822 | Phase 2 | Aug 1, 2012 | Cesa Projects International |
| NCT01046929 | Phase 1 | Aug 1, 2009 | National Cancer Institute (NCI), University of Arizona |
Showing 5 of 5 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Stanford University | Academic/Hospital | 2 | 2 | 1 | 2016 |
| Cesa Projects International | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Government of Russia | Government | 1 | 1 | 1 | 2018 |
| I.M. Sechenov First Moscow State Medical University | Academic/Hospital | 1 | 0 | 1 | 2018 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2009 |
| University of Arizona | Academic/Hospital | 1 | 1 | 1 | 2009 |
6 organizations
Page 1 / 1