azd-2624
Small moleculeexperimental
Clinical trial activity
6 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2008 (NCT00696865)
Timeline
Indications
Mechanism of action
- Neurokinin 3 receptorANTAGONIST
TACR3 antagonist
Chemistry & pharmacology
Loading structure…
SMILES
CC[C@H](NC(=O)c1c(NS(C)(=O)=O)c(-c2ccccc2)nc2ccccc12)c1ccccc1- Mol. weight
- 459.57 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3545233 ↗
Also known as
- 3-((methylsulfonyl)amino)-2-phenyl-n-(1-phenylpropyl)quinolin-4-carboxamide
- azd2624
- azd2624
- azd2624
- azd2624
- azd 2624
- azd-2624
- azd-2624
- azd-2624
- azd-2624
- azd4901
- azd4901
- mle4901
- mle4901
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02865915 | Phase 2 | Jul 1, 2016 | Covance, Medpace, Inc., Millendo Therapeutics, Inc. |
| NCT02668185 | Phase 2 | Feb 1, 2016 | AstraZeneca, Medical Research Council, National Institute for Health Research, United Kingdom, University of London |
| NCT01872078 | Phase 2 | Jun 1, 2013 | AstraZeneca, University of Oxford |
| NCT00867685 | Phase 1 | Mar 1, 2009 | AstraZeneca |
| NCT00686998 | Phase 2 | May 1, 2008 | AstraZeneca |
| NCT00696865 | Phase 1 | May 1, 2008 | AstraZeneca, Kitasato University |
Showing 6 of 6 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| AstraZeneca | For profit | 5 | 4 | 2 | 2008 |
| Covance | For profit | 1 | 0 | 1 | 2016 |
| Kitasato University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Medical Research Council | Government | 1 | 0 | 1 | 2016 |
| Medpace, Inc. | For profit | 1 | 0 | 1 | 2016 |
| Millendo Therapeutics, Inc. | For profit | 1 | 1 | 1 | 2016 |
| National Institute for Health Research, United Kingdom | Government | 1 | 0 | 1 | 2016 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Oxford | Academic/Hospital | 1 | 0 | 1 | 2013 |
9 organizations
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