silver diammine fluoride
Silver diammine fluoride (SDF), also known as silver diamine fluoride in most of the dental literature, is a topical medication used to treat and prevent dental caries and relieve dentinal hypersensitivity. It is a colorless or blue-tinted, odourless liquid composed of silver, ammonium and fluoride ions at a pH of 10.4 or 13. Ammonia compounds reduce the oxidative potential of SDF, increase its stability and helps to maintain a constant concentration over a period of time, rendering it safe for use in the mouth. Silver and fluoride ions possess antimicrobial properties and are used in the remineralization of enamel and dentin on teeth for preventing and arresting dental caries. — Wikipedia
Clinical trial activity
59 trials · 40 clinical orgs · 0 marketing orgs
Earliest trial started Jan 1, 2012 (NCT02360124)
Timeline
Indications
Approved for
Studied for
- Aged · Phase 4
- Child Behavior · Phase 4
- Dental Caries · Phase 4
- Dental Pulp · Phase 2/Phase 3
- Dentin · Phase 2/Phase 3
- Dentist's Role · Phase 2
- Fluorides · Phase 4
- Gastrointestinal Microbiome · Phase 3
- Orthodontic Appliances, Fixed · Phase 2
- Pediatrics · Phase 2/Phase 3
- Quality of Life · Phase 4
- Tooth · Phase 3
- Tooth Abnormalities · Phase 2
- Tooth, Deciduous · Phase 3
- Tooth Demineralization · Phase 2
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
SMILES
N.N.[Ag+].[F-]- Mol. weight
- 160.93 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- Yes
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaSilver diammine fluoride ↗
- ChEMBLCHEMBL4297206 ↗
Also known as
- diamminefluorosilver
- diammine silver fluoride
- sdf
- silver ammonia fluoride
- silver diamine fluoride
- silver diamine fluoride
- silver diamine fluoride
- silver diammine fluoride
- silver fluoride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07194629 | Phase 4 | Oct 1, 2025 | University of Montreal |
| NCT07181967 | N/A | Sep 15, 2025 | Assiut University |
| NCT06797882 | Phase 2 | Jan 31, 2025 | National University of Malaysia |
| NCT06489093 | Early Phase 1 (Phase 1) | Jul 29, 2024 | Plovdiv Medical University |
| NCT06241261 | Phase 2 | Jan 1, 2024 | The University of Hong Kong |
| NCT06699199 | Phase 4 | Nov 1, 2023 | King Abdul-Aziz University |
| NCT05941429 | Phase 1 | Aug 31, 2023 | Cairo University |
| NCT06316323 | Phase 1 | Feb 1, 2023 | Universiti Teknologi Mara |
| NCT05655286 | N/A | Jan 1, 2023 | The University of Hong Kong |
| NCT06293547 | N/A | Aug 10, 2022 | Cumhuriyet University |
| NCT05425368 | N/A | Aug 1, 2022 | Cairo University |
| NCT05337449 | N/A | Jul 15, 2022 | Cairo University |
| NCT05249231 | N/A | Apr 30, 2022 | Cairo University |
| NCT05255913 | N/A | Mar 31, 2022 | Alexandria University |
| NCT05761041 | Phase 3 | Mar 28, 2022 | Alexandria University |
| NCT05221749 | Phase 3 | Mar 15, 2022 | Alexandria University |
| NCT05485272 | N/A | Feb 1, 2022 | Cairo University |
| NCT05188846 | Phase 3 | Jan 25, 2022 | Cairo University |
| NCT05772039 | Phase 4 | Jan 18, 2022 | SDI Limited, Univerisiti Sains Malaysia |
| NCT04889196 | Phase 3 | Sep 1, 2021 | Cairo University |
Organizations
Research & Development (40)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cairo University | Academic/Hospital | 15 | 15 | 4 | 2017 |
| The University of Hong Kong | Academic/Hospital | 9 | 9 | 3 | 2012 |
| Alexandria University | Academic/Hospital | 7 | 7 | 3 | 2018 |
| Mansoura University | Academic/Hospital | 3 | 3 | 2 | 2019 |
| University of Iowa | Academic/Hospital | 2 | 1 | 2 | 2016 |
| Advantage Dental | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Advantage Silver Dental Arrest, LLC | For profit | 1 | 1 | 1 | 2019 |
| Ain Shams University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Al Azhar University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Assiut University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Beaty Dent | For profit | 1 | 1 | 1 | 2021 |
| British University In Egypt | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Cumhuriyet University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Federal University of Rio de Janeiro | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Fluminense Federal University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Fundação de Amparo à Pesquisa do Estado de São Paulo | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Jordan University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| King Abdul-Aziz University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| King Abdullah Medical City | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Kuwait University | Academic/Hospital | 1 | 1 | 1 | 2015 |