camphor

Small moleculeexperimental

Camphor is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora. Topically, camphor is used to relieve pain. It has been used to treat warts, cold sores, hemorrhoids, and osteoarthritis. It has also been applied topically as an analgesic and an antipruritic. It has been used as a counterirritant, and to increase local blood flow. Camphor has frequently been used topically to treat respiratory tract diseases involving mucous membrane inflammation. It is sometimes used topically to treat cardiac symptoms. Camphor is also used topically as an eardrop, and for treating minor burns. In inhalation therapy, camphor is used as an antitussive. Orally, camphor is used as an expectorant, antiflatulent, and for treating respiratory tract diseases. Today, most camphor is synthetic. It is approved by the FDA as a topical antitussive. Camphor is produced synthetically from the oil of turpentine. It has been used for centuries for its medicinal features, in religious rituals, and in cooking. It is no longer used as pesticide. In 1982, the US Food and Drug Administration restricted commercial products intended for medicinal use to contain <11% camphor. — NCATS

Clinical trial activity

2 trials · 2 clinical orgs · 0 marketing orgs

Phase 1
1
Phase 2
1
Phase 3
1
Phase 4
0

Earliest trial started May 1, 2011 (NCT01119534)

Timeline

2010s

  1. Jan 1, 2011

    Earliest Phase 3 Sponsor(trial)

2020s

  1. Jan 1, 2024

    Earliest Phase 1 Sponsor(trial)

Indications

Mechanism of action

  • Unspecified targetOTHER

    Unknown

    Camphor has been pharmaceutically applied as an analgesic, antipruritic, antispasmodic, anti-inflammatory rubefacient. In addition, camphor has been used as an antiseptic, contraceptive, aphrodisiac, and lactation suppressant. Because camphor has mild expectant, nasal decongestant, and cough-suppressant effects, camphor in ointments, oils, and inhalants has been widely used as a home treatment for colds.

Chemistry & pharmacology

Loading structure…

SMILES

CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2
Mol. weight
152.2334 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • (1r,4r)-camphor
  • (1r,4r)-camphor
  • (1r)-(+)-camphor
  • (1r)-(+)-camphor
  • 2-bornanone
  • 2-camphanone
  • alphanon
  • (+)-bornan-2-one
  • (+)-bornan-2-one
  • borneo camphor
  • camphor
  • camphor
  • camphor
  • camphor
  • camphor
  • camphor
  • camphor
  • camphor
  • camphor
  • camphor
  • (+)-camphor
  • (+)-camphor
  • camphor, (+/-)-
  • camphora
  • camphora
  • camphora
  • camphora
  • camphor(d)
  • camphor(d)
  • camphor d-form
  • camphor d-form
  • camphor (natural)
  • camphor oil
  • camphor oil
  • camphor (synthetic)
  • camphor, (synthetic)
  • d-camphor
  • d-camphor
  • d-camphor
  • dextrocamphor
  • dextrocamphor
  • dl-camphor
  • dl-camphor
  • dl-camphor
  • natural camphor
  • natural camphor
  • pi-oxocamphor
  • pi-oxocamphor, trans-(+)-isomer
  • (r)-camphor
  • (r)-camphor
  • (r)-(+)-camphor
  • (r)-(+)-camphor
  • root bark oil
  • synthetic camphor
  • synthetic camphor
  • trans-pi-oxocamphor
  • trans-pi-oxocamphor
  • trans-pi-oxocamphor

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06444594Early Phase 1 (Phase 1)Jun 15, 2024Pennsylvania State University
NCT01119534Phase 3May 1, 2011Azidus
Showing 2 of 2 trials
Page 1 / 1

Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
AzidusFor profit1112011
Pennsylvania State UniversityAcademic/Hospital1112024
2 organizations
Page 1 / 1