camphor
Camphor is a bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora. Topically, camphor is used to relieve pain. It has been used to treat warts, cold sores, hemorrhoids, and osteoarthritis. It has also been applied topically as an analgesic and an antipruritic. It has been used as a counterirritant, and to increase local blood flow. Camphor has frequently been used topically to treat respiratory tract diseases involving mucous membrane inflammation. It is sometimes used topically to treat cardiac symptoms. Camphor is also used topically as an eardrop, and for treating minor burns. In inhalation therapy, camphor is used as an antitussive. Orally, camphor is used as an expectorant, antiflatulent, and for treating respiratory tract diseases. Today, most camphor is synthetic. It is approved by the FDA as a topical antitussive. Camphor is produced synthetically from the oil of turpentine. It has been used for centuries for its medicinal features, in religious rituals, and in cooking. It is no longer used as pesticide. In 1982, the US Food and Drug Administration restricted commercial products intended for medicinal use to contain <11% camphor. — NCATS
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Earliest trial started May 1, 2011 (NCT01119534)
Timeline
Indications
Approved for
Studied for
Mechanism of action
- Unspecified targetOTHER
Unknown
Camphor has been pharmaceutically applied as an analgesic, antipruritic, antispasmodic, anti-inflammatory rubefacient. In addition, camphor has been used as an antiseptic, contraceptive, aphrodisiac, and lactation suppressant. Because camphor has mild expectant, nasal decongestant, and cough-suppressant effects, camphor in ointments, oils, and inhalants has been widely used as a home treatment for colds.
Chemistry & pharmacology
SMILES
CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2- Mol. weight
- 152.2334 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCamphor ↗
- NCATS5TJD82A1ET ↗
- ChEMBLCHEMBL504760 ↗
- ChEMBLCHEMBL15768 ↗
Also known as
- (1r,4r)-camphor
- (1r,4r)-camphor
- (1r)-(+)-camphor
- (1r)-(+)-camphor
- 2-bornanone
- 2-camphanone
- alphanon
- (+)-bornan-2-one
- (+)-bornan-2-one
- borneo camphor
- camphor
- camphor
- camphor
- camphor
- camphor
- camphor
- camphor
- camphor
- camphor
- camphor
- (+)-camphor
- (+)-camphor
- camphor, (+/-)-
- camphora
- camphora
- camphora
- camphora
- camphor(d)
- camphor(d)
- camphor d-form
- camphor d-form
- camphor (natural)
- camphor oil
- camphor oil
- camphor (synthetic)
- camphor, (synthetic)
- d-camphor
- d-camphor
- d-camphor
- dextrocamphor
- dextrocamphor
- dl-camphor
- dl-camphor
- dl-camphor
- natural camphor
- natural camphor
- pi-oxocamphor
- pi-oxocamphor, trans-(+)-isomer
- (r)-camphor
- (r)-camphor
- (r)-(+)-camphor
- (r)-(+)-camphor
- root bark oil
- synthetic camphor
- synthetic camphor
- trans-pi-oxocamphor
- trans-pi-oxocamphor
- trans-pi-oxocamphor
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06444594 | Early Phase 1 (Phase 1) | Jun 15, 2024 | Pennsylvania State University |
| NCT01119534 | Phase 3 | May 1, 2011 | Azidus |
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Azidus | For profit | 1 | 1 | 1 | 2011 |
| Pennsylvania State University | Academic/Hospital | 1 | 1 | 1 | 2024 |