azd-1446

Small moleculeexperimental

Clinical trial activity

11 trials · 4 clinical orgs · 0 marketing orgs

Phase 1
8
Phase 2
3
Phase 3
0
Phase 4
0

Earliest trial started Dec 1, 2008 (NCT00803855)

Timeline

2000s

  1. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2009

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

O=C(c1ccc(Cl)o1)N1CC2CNCC2C1
Mol. weight
240.69 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Racemic Mixture
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 3-(5-chloro-2-furoyl)-3,7-diazabicyclo(3.3.0)octane
  • azd1446
  • azd1446
  • azd1446
  • azd1446
  • azd-1446
  • azd-1446
  • tc-6683
  • tc-6683
  • tc-6683

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT01199315Phase 1Sep 1, 2010AstraZeneca, Kyushu Clinical Pharmacolgy Reasearch Clinic
NCT01125683Phase 2Jun 1, 2010AstraZeneca
NCT01092299Phase 1Feb 1, 2010AstraZeneca, IQVIA
NCT01021189Phase 1Dec 1, 2009AstraZeneca, Kyushu Clinical Pharmacolgy Reasearch Clinic
NCT01039701Phase 2Dec 1, 2009AstraZeneca
NCT01044342Phase 1Dec 1, 2009AstraZeneca
NCT01012375Phase 2Nov 1, 2009AstraZeneca, University of Vermont
NCT00997308Phase 1Oct 1, 2009AstraZeneca
NCT00902993Phase 1Apr 1, 2009AstraZeneca
NCT00886067Phase 1Apr 1, 2009AstraZeneca
NCT00803855Phase 1Dec 1, 2008AstraZeneca
Showing 11 of 11 trials
Page 1 / 1

Organizations

Research & Development (4)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
AstraZenecaFor profit111122008
Kyushu Clinical Pharmacolgy Reasearch ClinicAcademic/Hospital2012009
IQVIAFor profit1012010
University of VermontAcademic/Hospital1012009
4 organizations
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